L1 binds NRP1

Stable Identifier
R-HSA-374669
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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L1 interacts with neuropilin 1 (NP-1) through a conserved sequence (FASNKL) present with in the Ig1 domain of L1 and this association is required as a part of semaphorin 3A (Sema3A) receptor complex for axon guidance responses.
L1 interacts with NP-1 in cis to form a receptor complex that induces repulsive turning of the growth cone in response to Sema3A binding, whereas trans interaction of L1 with NP-1 switches Sema3A triggered repulsion to attraction.

Literature References
PubMed ID Title Journal Year
12456642 Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A

Castellani, V, De Angelis, E, Kenwrick, S, Rougon, G

EMBO J 2002
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