Reactome | PDYN(226-238) [extracellular region]

PDYN(226-238) [extracellular region]

Stable Identifier

R-HSA-374383

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Dynorphin-B, PDYN_HUMAN, PDYN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Opioid receptors bind opioid peptides (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)
        
        Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
        
        Opioid ligands [extracellular region] (Homo sapiens)
        
        Dynorphins [extracellular region] (Homo sapiens)
        
        PDYN(226-238) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01213 PDYN

Gene Names

PDYN

Chain

signal peptide:1-20, propeptide:21-172, peptide:175-184, peptide:175-183, peptide:175-179, propeptide:186-204, peptide:207-238, peptide:207-223, peptide:207-219, peptide:207-214, peptide:207-211, peptide:226-254, peptide:226-238, peptide:226-230

Reference Genes

BioGPS Gene:5173 PDYN

COSMIC (genes):PDYN PDYN

CTD Gene:5173 PDYN

dbSNP Gene:5173 PDYN

ENSEMBL:ENSG00000101327 PDYN

HGNC:8820 PDYN

KEGG:hsa:5173 PDYN

Monarch:5173 PDYN

NCBI Gene:5173 PDYN

OMIM:131340 PDYN

UCSC:P01213 PDYN

Reference Transcript

Other Identifiers

11729209_at

11751374_a_at

11757042_a_at

16916536

206803_PM_at

206803_at

35954_at

3894907

3894908

3894909

3894910

3894911

3894912

3894913

3894915

3894916

3894917

5173

8064495

A_23_P40262

A_24_P279870

GE80263

GO:0001515

GO:0005515

GO:0005576

GO:0005886

GO:0007218

GO:0007268

GO:0007600

GO:0023052

GO:0030425

GO:0031410

GO:0031628

GO:0043025

GO:0043226

GO:0043679

GO:0045202

GO:0048018

GO:0050877

GO:0098686

GO:0098772

GO:0098992

HMNXSV003002417

ILMN_1747019

K02268_at

PH_hs_0001975

TC20000558.hg

g13270472_3p_at

Participates

as a member of

Dynorphins [extracellular region] (Homo sapiens)

Other forms of this molecule

PDYN(207-223) [extracellular region]

PDYN(175-183) [extracellular region]

PDYN(207-238) [extracellular region]

PDYN(175-184) [extracellular region]

PDYN(226-230) [extracellular region]

Inferred To

PDYN [extracellular region] (Bos taurus)

PDYN [extracellular region] (Canis familiaris)

PDYN [extracellular region] (Sus scrofa)

pdyn [extracellular region] (Xenopus tropicalis)

Pdyn [extracellular region] (Mus musculus)

Pdyn [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

XP_011527551.1, XP_011527550.1, NP_001177829.1, NP_001177828.1, XP_011527548.1, NP_077722.1, XP_011527549.1, NP_001177821.1, NP_001177827.1, XP_011527546.1, XP_016883367.1, XP_011527547.1, XP_011527552.1

OpenTargets

ENSG00000101327

ENSEMBL

ENST00000217305, ENSP00000440185, ENSP00000217305, ENST00000540134, ENST00000539905, ENSP00000442259

ZINC - Substances

PDYN_HUMAN

ZINC - Biogenic

PDYN_HUMAN

ZINC target

P01213

PRO

P01213

PDB

7Y1F, 2N2F, 8F7W

ZINC - Metabolites

PDYN_HUMAN

HPA

ENSG00000101327-PDYN

Pharos - Targets

P01213

Orphanet

PDYN

ZINC - Predictions - Purchasable

PDYN_HUMAN

HMDB Protein

HMDBP13363

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.527	3