Apelin receptor binds to apelin

Stable Identifier
R-HSA-374337
Type
Reaction [binding]
Species
Homo sapiens
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Apelin (Tatemoto K et al, 1998) is an endogenous ligand for the apelin (APJ) receptor (O'Dowd BF et al, 1993) and is widely expressed in the human body including the heart and brain. Apelin is one of the most potent stimulators of cardiac contractility and mediates blood pressure and blood flow. Several active peptides can be produced by proteolytic processing of the peptide precursor (apelin-36, 31, 28 and 13). APJ is related to the angiotensin receptor (40-50% identity) and couples to G proteins that inhibit adenylate cyclase activity. It is an alternative coreceptor with CD4 for HIV-1 infection. Binding of apelin to its receptor inhibits HIV-1 entry in cells coexpressing CD4 and APJ.

Literature References
PubMed ID Title Journal Year
8294032 A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

O'Dowd, BF, Heiber, M, Chan, A, Heng, HH, Tsui, LC, Kennedy, JL, Shi, X, Petronis, A, George, SR, Nguyen, T

Gene 1993
9792798 Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

Tatemoto, K, Hosoya, M, Habata, Y, Fujii, R, Kakegawa, T, Zou, MX, Kawamata, Y, Fukusumi, S, Hinuma, S, Kitada, C, Kurokawa, T, Onda, H, Fujino, M

Biochem Biophys Res Commun 1998
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