Reactome | APLN(65-77) [extracellular region]

APLN(65-77) [extracellular region]

Stable Identifier

R-HSA-374315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Apelin-13, APEL_HUMAN, APLN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Apelin receptor binds to apelin (Homo sapiens)
        
        APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)
        
        Apelin peptides [extracellular region] (Homo sapiens)
        
        APLN(65-77) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9ULZ1 APLN

Gene Names

APLN, APEL

Chain

signal peptide:1-22, propeptide:23-41, peptide:42-77, peptide:47-77, peptide:50-77, peptide:65-77

Reference Genes

BioGPS Gene:8862 APLN

COSMIC (genes):APLN APLN

CTD Gene:8862 APLN

dbSNP Gene:8862 APLN

ENSEMBL:ENSG00000171388 APLN

HGNC:16665 APLN

KEGG Gene (Homo sapiens):8862 APLN

Monarch:8862 APLN

NCBI Gene:8862 APLN

OMIM:300297 APLN

UCSC:Q9ULZ1 APLN

Reference Transcript

RefSeq:NM_017413.4 APLN

Other Identifiers

0002450059

11724665_at

17114007

222856_PM_at

222856_at

4021274

4021275

4021276

4021277

4021278

4021279

4021280

4021281

4021283

4021284

4021285

4021294

4021295

60846_at

8175016

8862

A_23_P113393

A_23_P147755

A_24_P404822

GE82161

GE87422

GO:0001525

GO:0002376

GO:0003013

GO:0003674

GO:0005102

GO:0005179

GO:0005575

GO:0005576

GO:0005615

GO:0006810

GO:0006955

GO:0007165

GO:0007369

GO:0007595

GO:0008150

GO:0008283

GO:0009058

GO:0009790

GO:0010629

GO:0016192

GO:0031704

GO:0034641

GO:0040037

GO:0042756

GO:0045776

GO:0045823

GO:0048646

GO:0048856

GO:0060183

GO:0060976

GO:1902895

GO:1904022

GO:1904706

GO:1905564

HMNXSV003033792

Hs.303084.0.S3_3p_at

ILMN_1689353

PH_hs_0015648

TC0X001354.hg

Participates

as a member of

Apelin peptides [extracellular region] (Homo sapiens)

Other forms of this molecule

APLN(50-77) [extracellular region]

APLN(42-77) [extracellular region]

APLN(47-77) [extracellular region]

Inferred To

APLN [extracellular region] (Bos taurus)

APLN [extracellular region] (Canis familiaris)

APLN [extracellular region] (Gallus gallus)

APLN [extracellular region] (Sus scrofa)

apln [extracellular region] (Danio rerio)

apln [extracellular region] (Xenopus tropicalis)

Apln [extracellular region] (Mus musculus)

Apln [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_059109.3

OpenTargets

ENSG00000171388

GeneCards

Q9ULZ1

HPA

ENSG00000171388-APLN

ZINC target

Q9ULZ1

Ensembl

ENSP00000391800, ENST00000429967, ENSG00000171388

PRO

Q9ULZ1

Pharos - Targets

Q9ULZ1

Orphanet

25434

HMDB Protein

HMDBP12613

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