Reactome | APLNR [plasma membrane]

APLNR [plasma membrane]

Stable Identifier

R-HSA-374259

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Apelin receptor, APJ_HUMAN, AGTRL1

Locations in the PathwayBrowser for interactor UniProt:Q9Y397 ZDHHC9

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External Reference Information

External Reference

UniProt:P35414 APLNR

Gene Names

APLNR, AGTRL1, APJ

Chain

chain:1-380

Reference Genes

BioGPS Gene:187 APLNR

COSMIC (genes):APLNR APLNR

CTD Gene:187 APLNR

dbSNP Gene:187 APLNR

ENSEMBL:ENSG00000134817 APLNR

ENSEMBL_homo_sapiens_GENE:ENSG00000134817.12 APLNR

HGNC:339 APLNR

KEGG Gene (Homo sapiens):187 APLNR

Monarch:187 APLNR

NCBI Gene:187 APLNR

OMIM:600052 APLNR

UCSC:P35414 APLNR

Reference Transcript

RefSeq:NM_005161.4 APLNR

Other Identifiers

11722792_a_at

11754410_s_at

16738400

184_at

187

213592_3p_at

213592_PM_at

213592_at

3373639

3373640

3373641

3373642

3373643

3373644

3373645

3373646

3373647

3373648

55636_at

7948167

A_23_P318860

GE60119

GE80348

GO:0001525

GO:0001568

GO:0001570

GO:0001944

GO:0001947

GO:0003171

GO:0003272

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007369

GO:0007507

GO:0007512

GO:0010468

GO:0010629

GO:0016020

GO:0023052

GO:0030154

GO:0034330

GO:0035886

GO:0035904

GO:0036211

GO:0038023

GO:0043951

GO:0045766

GO:0048856

GO:0050878

GO:0051281

GO:0055065

GO:0055085

GO:0060089

GO:0060182

GO:0060183

GO:0060412

GO:0060841

GO:0060976

GO:1903589

GO:1903596

GO:1904325

HMNXSV003051153

Hs.9305.0.S2_3p_at

Hs.9305.0.S2_3p_s_at

ILMN_1700183

PH_hs_0020741

TC11001786.hg

TC11003162.hg

U03642_at

Participates

as an input of

Apelin receptor binds to apelin (Homo sapiens)

as a component of

APLNR:Apelin peptides [plasma membrane] (Homo sapiens)

Inferred To

aplnrb [plasma membrane] (Danio rerio)

Aplnr [plasma membrane] (Mus musculus)

Aplnr [plasma membrane] (Rattus norvegicus)

APLNR1 [plasma membrane] (Gallus gallus)

Homologues of APLNR [plasma membrane] (Danio rerio)

APLNR [plasma membrane] (Bos taurus)

APLNR [plasma membrane] (Sus scrofa)

aplnra [plasma membrane] (Danio rerio)

aplnr2 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_005152.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000134817

ZINC - Substances

APJ_HUMAN

ZINC target

P35414

PRO

P35414

PDB

7W0P, 2LOV, 8XZH, 7W0M, 2LOW, 8XZG, 7W0L, 7W0N, 7SUS, 8XZF, 8XZJ, 7W0O, 5VBL, 2LOT, 6KNM, 2LOU, 8XZI

HPA

ENSG00000134817-APLNR

GeneCards

P35414

Ensembl

ENSP00000257254, ENST00000257254, ENSG00000134817, ENSP00000475344, ENST00000606794

Pharos - Targets

P35414

ZINC - Predictions - Purchasable

APJ_HUMAN

HMDB Protein

HMDBP12615

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30556 AGTR1	2	AGTR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869071) AGTR1 [plasma membrane] (R-HSA-374247)	0.713	14
UniProt:P41145 OPRK1	1	OPRK1 [plasma membrane] (R-HSA-374286)	0.654	4
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:O43613 HCRTR1	1	HCRTR1 [plasma membrane] (R-HSA-389490)	0.556	6
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.527	2
UniProt:P33981 TTK			0.527	2
UniProt:P10588 NR2F6	1	NR2F6 [nucleoplasm] (R-HSA-376279)	0.527	2
UniProt:Q9H0H0 INTS2	1	INTS2 [nucleoplasm] (R-HSA-6807448)	0.527	2
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:Q9BV35 SCMC3			0.527	2
UniProt:Q96E22 NUS1	1	NUS1 [endoplasmic reticulum membrane] (R-HSA-6806946)	0.527	2
UniProt:Q96CW5 TUBGCP3	1	TUBGCP3 [cytosol] (R-HSA-379276)	0.527	3
UniProt:Q6JQN1 ACAD10	1	ACAD10 [mitochondrial matrix] (R-HSA-5695955)	0.527	2
UniProt:Q6DD88 ATLA3			0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	3
UniProt:Q02338 BDH1	1	BDH1 [mitochondrial matrix] (R-HSA-73922)	0.527	2
UniProt:Q9NYP7 ELOVL5	1	ELOVL5 [endoplasmic reticulum membrane] (R-HSA-548679)	0.527	2
UniProt:Q9NVN8 GNL3L			0.527	2
UniProt:O00400 SLC33A1	4	SLC33A1 A110P [Golgi membrane] (R-HSA-5649754) SLC33A1 S113R [Golgi membrane] (R-HSA-5649751) SLC33A1 Y366* [Golgi membrane] (R-HSA-5649750) SLC33A1 [Golgi membrane] (R-HSA-727745)	0.527	3
UniProt:Q96AG3 S2546			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	3
UniProt:Q8NE86 MCU	1	MCU [mitochondrial inner membrane] (R-HSA-8949184)	0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:Q6NZ67 MZT2B	1	MZT2B [cytosol] (R-HSA-8955057)	0.527	2
UniProt:Q99808 SLC29A1	1	SLC29A1 [plasma membrane] (R-HSA-54335)	0.527	2
UniProt:P20337 RAB3B	2	GGC-RAB3B [cytosol] (R-HSA-8874009) RAB3B [cytosol] (R-HSA-8873715)	0.527	2
UniProt:Q29RF7 PDS5A	4	PDS5A [cytosol] (R-HSA-2484799) PDS5A [chromosome] (R-HSA-2466360) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [nucleoplasm] (R-HSA-2468043)	0.527	3
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.527	2
UniProt:Q9NUQ2 AGPAT5	2	AGPAT5 [mitochondrial outer membrane] (R-HSA-1500585) AGPAT5 [endoplasmic reticulum membrane] (R-HSA-61811)	0.527	3
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.527	2
UniProt:P00395 MT-CO1	1	nascent MT-CO1 [mitochondrial inner membrane] (R-HSA-164314)	0.527	2
UniProt:A6NJ78 MET15			0.527	2
UniProt:Q6Y1H2 HACD2	1	PTPLB [endoplasmic reticulum membrane] (R-HSA-5676075)	0.527	2
UniProt:Q6NXR4 TTI2			0.527	2
UniProt:Q0P651 ABD18			0.527	2
UniProt:Q2PZI1 D19L1			0.527	2
UniProt:Q9NWR8 MCUB	1	MCUB [mitochondrial inner membrane] (R-HSA-8949153)	0.527	2
UniProt:Q9UQ90 SPG7	1	SPG7 [mitochondrial inner membrane] (R-HSA-8953712)	0.527	2
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	3
UniProt:Q8NBP5 MFSD9			0.527	2
UniProt:P33897 ABCD1	8	ABCD1 R617C [peroxisomal membrane] (R-HSA-5685069) ABCD1 T77_L82del [peroxisomal membrane] (R-HSA-5685088) ABCD1 S606L [peroxisomal membrane] (R-HSA-5685104) ABCD1 [peroxisomal membrane] (R-HSA-382566) ABCD1 [cytosol] (R-HSA-382587) ABCD1 G277R [peroxisomal membrane] (R-HSA-5685058) ABCD1 M1V [peroxisomal membrane] (R-HSA-5685059) ABCD1 R554H [peroxisomal membrane] (R-HSA-5685072)	0.527	2
UniProt:O15360 FANCA	2	FANCA [nucleoplasm] (R-HSA-419541) FANCA [cytosol] (R-HSA-420796)	0.527	3
UniProt:P84085 ARF5	1	ARF5 [cytosol] (R-HSA-6807737)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:Q5VYK3 ECM29			0.527	3
UniProt:Q86Y56 DAAF5			0.527	2
UniProt:Q9UFG5 CS025			0.527	2
UniProt:O14981 BTAF1			0.527	3
UniProt:O14980 XPO1	2	XPO1 [nucleoplasm] (R-HSA-165529) XPO1 [cytosol] (R-HSA-165539)	0.527	2
UniProt:Q8TD22 SFXN5			0.527	2
UniProt:Q5U3C3 TM164			0.527	2
UniProt:Q6PJG6 BRAT1			0.527	3
UniProt:Q9Y397 ZDHHC9	1	ZDHHC9 [Golgi membrane] (R-HSA-9647931)	0.527	2
UniProt:P53794 SLC5A3	1	SLC5A3 [plasma membrane] (R-HSA-429592)	0.527	2
UniProt:P03886 MT-ND1	1	MT-ND1 [mitochondrial inner membrane] (R-HSA-60551)	0.527	3
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.527	2
UniProt:P51857 AKR1D1	1	AKR1D1 [cytosol] (R-HSA-191975)	0.527	2
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.527	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.463	3

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