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APLNR [plasma membrane]
Stable Identifier
R-HSA-374259
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Apelin receptor, APJ_HUMAN, AGTRL1
Locations in the PathwayBrowser for interactor UniProt:P23458 JAK1
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Apelin receptor binds to apelin (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35414 APLNR
Gene Names
APLNR, AGTRL1, APJ
Chain
chain:1-380
Reference Genes
BioGPS Gene:187 APLNR
COSMIC (genes):APLNR APLNR
CTD Gene:187 APLNR
dbSNP Gene:187 APLNR
ENSEMBL:ENSG00000134817 APLNR
ENSEMBL_homo_sapiens_GENE:ENSG00000134817.12 APLNR
HGNC:339 APLNR
KEGG Gene (Homo sapiens):187 APLNR
Monarch:187 APLNR
NCBI Gene:187 APLNR
OMIM:600052 APLNR
UCSC:P35414 APLNR
Reference Transcript
RefSeq:NM_005161.4 APLNR
Other Identifiers
11722792_a_at
11754410_s_at
16738400
184_at
187
213592_3p_at
213592_PM_at
213592_at
3373639
3373640
3373641
3373642
3373643
3373644
3373645
3373646
3373647
3373648
55636_at
7948167
A_23_P318860
GE60119
GE80348
GO:0001525
GO:0001568
GO:0001570
GO:0001944
GO:0001947
GO:0003171
GO:0003272
GO:0004930
GO:0005515
GO:0005886
GO:0007165
GO:0007186
GO:0007369
GO:0007507
GO:0007512
GO:0010468
GO:0010629
GO:0016020
GO:0023052
GO:0030154
GO:0034330
GO:0035886
GO:0035904
GO:0036211
GO:0038023
GO:0043951
GO:0045766
GO:0048856
GO:0050878
GO:0051281
GO:0055065
GO:0055085
GO:0060089
GO:0060182
GO:0060183
GO:0060412
GO:0060841
GO:0060976
GO:1903589
GO:1903596
GO:1904325
HMNXSV003051153
Hs.9305.0.S2_3p_at
Hs.9305.0.S2_3p_s_at
ILMN_1700183
PH_hs_0020741
TC11001786.hg
TC11003162.hg
U03642_at
Participates
as an input of
Apelin receptor binds to apelin (Homo sapiens)
as a component of
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
Inferred To
aplnrb [plasma membrane]
(Danio rerio)
Aplnr [plasma membrane]
(Mus musculus)
Aplnr [plasma membrane]
(Rattus norvegicus)
APLNR1 [plasma membrane]
(Gallus gallus)
Homologues of APLNR [plasma membrane]
(Danio rerio)
APLNR [plasma membrane]
(Bos taurus)
APLNR [plasma membrane]
(Sus scrofa)
aplnra [plasma membrane]
(Danio rerio)
aplnr2 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_005152.1
Guide to Pharmacology - Targets
36
OpenTargets
ENSG00000134817
ZINC - Substances
APJ_HUMAN
ZINC target
P35414
PRO
P35414
PDB
7W0P
,
2LOV
,
8XZH
,
7W0M
,
2LOW
,
8XZG
,
7W0L
,
7W0N
,
7SUS
,
8XZF
,
8XZJ
,
7W0O
,
5VBL
,
2LOT
,
6KNM
,
2LOU
,
8XZI
HPA
ENSG00000134817-APLNR
GeneCards
P35414
Ensembl
ENSP00000257254
,
ENST00000257254
,
ENSG00000134817
,
ENSP00000475344
,
ENST00000606794
Pharos - Targets
P35414
ZINC - Predictions - Purchasable
APJ_HUMAN
HMDB Protein
HMDBP12615
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30556 AGTR1
2
AGTR1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869071)
AGTR1 [plasma membrane]
(R-HSA-374247)
0.713
14
UniProt:P41145 OPRK1
1
OPRK1 [plasma membrane]
(R-HSA-374286)
0.654
4
UniProt:P29033 GJB2
3
GJB2 [plasma membrane]
(R-HSA-53211)
GJB2 [endoplasmic reticulum membrane]
(R-HSA-1629779)
GJB2 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190614)
0.556
3
UniProt:O43613 HCRTR1
1
HCRTR1 [plasma membrane]
(R-HSA-389490)
0.556
6
UniProt:Q96CB8 INTS12
1
INTS12 [nucleoplasm]
(R-HSA-6807456)
0.527
2
UniProt:P33981 TTK
0.527
2
UniProt:P10588 NR2F6
1
NR2F6 [nucleoplasm]
(R-HSA-376279)
0.527
2
UniProt:Q9H0H0 INTS2
1
INTS2 [nucleoplasm]
(R-HSA-6807448)
0.527
2
UniProt:Q9H2C2 ARV1
1
ARV1 [endoplasmic reticulum membrane]
(R-HSA-5216144)
0.527
2
UniProt:P24468 NR2F2
1
NR2F2 [nucleoplasm]
(R-HSA-1183002)
0.527
2
UniProt:Q14746 COG2
2
COG2 [trans-Golgi network membrane]
(R-HSA-6813863)
COG2 [Golgi membrane]
(R-HSA-5216080)
0.527
2
UniProt:Q9BV35 SCMC3
0.527
2
UniProt:Q96E22 NUS1
1
NUS1 [endoplasmic reticulum membrane]
(R-HSA-6806946)
0.527
2
UniProt:Q96CW5 TUBGCP3
1
TUBGCP3 [cytosol]
(R-HSA-379276)
0.527
3
UniProt:Q6JQN1 ACAD10
1
ACAD10 [mitochondrial matrix]
(R-HSA-5695955)
0.527
2
UniProt:Q6DD88 ATLA3
0.527
2
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.527
3
UniProt:Q02338 BDH1
1
BDH1 [mitochondrial matrix]
(R-HSA-73922)
0.527
2
UniProt:Q9NYP7 ELOVL5
1
ELOVL5 [endoplasmic reticulum membrane]
(R-HSA-548679)
0.527
2
UniProt:Q9NVN8 GNL3L
0.527
2
UniProt:O00400 SLC33A1
4
SLC33A1 A110P [Golgi membrane]
(R-HSA-5649754)
SLC33A1 S113R [Golgi membrane]
(R-HSA-5649751)
SLC33A1 Y366* [Golgi membrane]
(R-HSA-5649750)
SLC33A1 [Golgi membrane]
(R-HSA-727745)
0.527
3
UniProt:Q96AG3 S2546
0.527
2
UniProt:O75146 HIP1R
3
HIP1R [cytosol]
(R-HSA-8868155)
HIP1R [Golgi membrane]
(R-HSA-434348)
HIP1R [cytoplasmic vesicle membrane]
(R-HSA-434201)
0.527
3
UniProt:Q8NE86 MCU
1
MCU [mitochondrial inner membrane]
(R-HSA-8949184)
0.527
2
UniProt:Q9UPQ8 DOLK
6
DOLK [endoplasmic reticulum membrane]
(R-HSA-449274)
DOLK M1I [endoplasmic reticulum membrane]
(R-HSA-4755593)
DOLK H408D [endoplasmic reticulum membrane]
(R-HSA-4755548)
DOLK C99S [endoplasmic reticulum membrane]
(R-HSA-4755602)
DOLK W304C [endoplasmic reticulum membrane]
(R-HSA-4755557)
DOLK Y441S [endoplasmic reticulum membrane]
(R-HSA-4755590)
0.527
2
UniProt:Q6NZ67 MZT2B
1
MZT2B [cytosol]
(R-HSA-8955057)
0.527
2
UniProt:Q99808 SLC29A1
1
SLC29A1 [plasma membrane]
(R-HSA-54335)
0.527
2
UniProt:P20337 RAB3B
2
GGC-RAB3B [cytosol]
(R-HSA-8874009)
RAB3B [cytosol]
(R-HSA-8873715)
0.527
2
UniProt:Q29RF7 PDS5A
4
PDS5A [cytosol]
(R-HSA-2484799)
PDS5A [chromosome]
(R-HSA-2466360)
PDS5A [chromosome, centromeric region]
(R-HSA-2468259)
PDS5A [nucleoplasm]
(R-HSA-2468043)
0.527
3
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.527
2
UniProt:Q9NUQ2 AGPAT5
2
AGPAT5 [mitochondrial outer membrane]
(R-HSA-1500585)
AGPAT5 [endoplasmic reticulum membrane]
(R-HSA-61811)
0.527
3
UniProt:Q96KP1 EXOC2
2
EXOC2 [plasma membrane]
(R-HSA-264887)
EXOC2 [cytosol]
(R-HSA-5623376)
0.527
2
UniProt:P00395 MT-CO1
1
nascent MT-CO1 [mitochondrial inner membrane]
(R-HSA-164314)
0.527
2
UniProt:A6NJ78 MET15
0.527
2
UniProt:Q6Y1H2 HACD2
1
PTPLB [endoplasmic reticulum membrane]
(R-HSA-5676075)
0.527
2
UniProt:Q6NXR4 TTI2
0.527
2
UniProt:Q0P651 ABD18
0.527
2
UniProt:Q2PZI1 D19L1
0.527
2
UniProt:Q9NWR8 MCUB
1
MCUB [mitochondrial inner membrane]
(R-HSA-8949153)
0.527
2
UniProt:Q9UQ90 SPG7
1
SPG7 [mitochondrial inner membrane]
(R-HSA-8953712)
0.527
2
UniProt:Q8N201 INTS1
1
INTS1 [nucleoplasm]
(R-HSA-6807446)
0.527
3
UniProt:Q8NBP5 MFSD9
0.527
2
UniProt:P33897 ABCD1
8
ABCD1 R617C [peroxisomal membrane]
(R-HSA-5685069)
ABCD1 T77_L82del [peroxisomal membrane]
(R-HSA-5685088)
ABCD1 S606L [peroxisomal membrane]
(R-HSA-5685104)
ABCD1 [peroxisomal membrane]
(R-HSA-382566)
ABCD1 [cytosol]
(R-HSA-382587)
ABCD1 G277R [peroxisomal membrane]
(R-HSA-5685058)
ABCD1 M1V [peroxisomal membrane]
(R-HSA-5685059)
ABCD1 R554H [peroxisomal membrane]
(R-HSA-5685072)
0.527
2
UniProt:O15360 FANCA
2
FANCA [nucleoplasm]
(R-HSA-419541)
FANCA [cytosol]
(R-HSA-420796)
0.527
3
UniProt:P84085 ARF5
1
ARF5 [cytosol]
(R-HSA-6807737)
0.527
2
UniProt:Q9UIA9 XPO7
0.527
2
UniProt:Q5VYK3 ECM29
0.527
3
UniProt:Q86Y56 DAAF5
0.527
2
UniProt:Q9UFG5 CS025
0.527
2
UniProt:O14981 BTAF1
0.527
3
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.527
2
UniProt:Q8TD22 SFXN5
0.527
2
UniProt:Q5U3C3 TM164
0.527
2
UniProt:Q6PJG6 BRAT1
0.527
3
UniProt:Q9Y397 ZDHHC9
1
ZDHHC9 [Golgi membrane]
(R-HSA-9647931)
0.527
2
UniProt:P53794 SLC5A3
1
SLC5A3 [plasma membrane]
(R-HSA-429592)
0.527
2
UniProt:P03886 MT-ND1
1
MT-ND1 [mitochondrial inner membrane]
(R-HSA-60551)
0.527
3
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.527
2
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.527
2
UniProt:P51857 AKR1D1
1
AKR1D1 [cytosol]
(R-HSA-191975)
0.527
2
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.527
3
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.527
2
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.463
3
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