Reactome | BDKRB2 [plasma membrane]

BDKRB2 [plasma membrane]

Stable Identifier

R-HSA-374255

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

B2 bradykinin receptor, BKRB2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
        
        Bradykinin receptor [plasma membrane] (Homo sapiens)
        
        BDKRB2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30411 BDKRB2

Gene Names

BDKRB2, BKR2

Chain

chain:1-391

Reference Genes

BioGPS Gene:624 BDKRB2

COSMIC (genes):BDKRB2 BDKRB2

CTD Gene:624 BDKRB2

dbSNP Gene:624 BDKRB2

ENSEMBL:ENSG00000168398 BDKRB2

HGNC:1030 BDKRB2

KEGG:hsa:624 BDKRB2

Monarch:624 BDKRB2

NCBI Gene:624 BDKRB2

OMIM:113503 BDKRB2

UCSC:P30411 BDKRB2

Reference Transcript

RefSeq:NM_000623.3 BDKRB2

Other Identifiers

11740588_at

11746532_s_at

16788023

205870_PM_at

205870_at

3550274

3550279

3550282

3550283

3550284

3550285

3550286

3550287

3550288

3550289

3550290

3550291

39309_at

39310_at

624

62824_at

7976560

A_23_P304897

GE63096

GO:0002020

GO:0003012

GO:0003013

GO:0003824

GO:0004435

GO:0004930

GO:0004947

GO:0005515

GO:0005768

GO:0005794

GO:0005886

GO:0006939

GO:0006954

GO:0007166

GO:0007169

GO:0007186

GO:0007204

GO:0008015

GO:0009651

GO:0016020

GO:0016787

GO:0019229

GO:0031410

GO:0031702

GO:0033137

GO:0042310

GO:0042311

GO:0043114

GO:0043226

GO:0043231

GO:0046982

GO:0050482

GO:0060089

GO:1902219

GO:1902239

GO:1990127

HMNXSV003035161

ILMN_1684086

PH_hs_0013287

TC14002310.hg

X86163_at

g4557358_3p_at

Participates

as a member of

Bradykinin receptor [plasma membrane] (Homo sapiens)

Inferred To

Tre1 [plasma membrane] (Drosophila melanogaster)

moody [plasma membrane] (Drosophila melanogaster)

Bdkrb2 [plasma membrane] (Canis familiaris)

Bdkrb2 [plasma membrane] (Mus musculus)

Bdkrb2 [plasma membrane] (Rattus norvegicus)

npr-25 [plasma membrane] (Caenorhabditis elegans)

EG:22E5.10 [plasma membrane] (Drosophila melanogaster)

Homologues of BDKRB2 [plasma membrane] (Drosophila melanogaster)

BDKRB2 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_000614.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000539359, ENSP00000450482, ENSP00000438376, ENST00000542454, ENSG00000168398, ENST00000554311, ENSP00000439459

OpenTargets

ENSG00000168398

ZINC - FDA approved

BKRB2_HUMAN

ZINC - Substances

BKRB2_HUMAN

ZINC target

P30411

PRO

P30411

GlyGen

P30411

PDB

7F6H, 7F6I, 7F2O

ZINC - Investigational

BKRB2_HUMAN

GeneCards

BDKRB2

HPA

ENSG00000168398-BDKRB2

Pharos - Targets

P30411

ZINC - Predictions - Purchasable

BKRB2_HUMAN

HMDB Protein

HMDBP07471

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