Reactome | AGTR1 [plasma membrane]

AGTR1 [plasma membrane]

Stable Identifier

R-HSA-374247

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Type-1 angiotensin II receptor, AGTR1_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - ARRB bind GPCRs (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        AGTR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30556 AGTR1

Gene Names

AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B

Chain

chain:1-359

Reference Genes

BioGPS Gene:185 AGTR1

COSMIC (genes):AGTR1 AGTR1

CTD Gene:185 AGTR1

dbSNP Gene:185 AGTR1

ENSEMBL:ENSG00000144891 AGTR1

ENSEMBL_homo_sapiens_GENE:ENSG00000144891.19 AGTR1

HGNC:336 AGTR1

KEGG Gene (Homo sapiens):185 AGTR1

Monarch:185 AGTR1

NCBI Gene:185 AGTR1

OMIM:106165 AGTR1

Reference Transcript

Other Identifiers

11725176_s_at

11740227_s_at

16946707

185

205357_PM_s_at

205357_s_at

208016_PM_s_at

208016_s_at

2647024

2647025

2647026

2647027

2647030

2647039

2647040

2647041

2647042

2647043

2647048

2647049

2647050

2647051

2647052

346_s_at

37983_at

8083240

88568_at

A_14_P106288

A_23_P166616

D13814_s_at

GE58228

GO:0001558

GO:0001596

GO:0001822

GO:0002018

GO:0002034

GO:0003013

GO:0003014

GO:0003081

GO:0004930

GO:0004945

GO:0005515

GO:0005886

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0007266

GO:0010744

GO:0016020

GO:0019229

GO:0019722

GO:0023052

GO:0030154

GO:0031711

GO:0032430

GO:0033864

GO:0034374

GO:0035813

GO:0038166

GO:0042127

GO:0046718

GO:0046982

GO:0048856

GO:0048870

GO:0050727

GO:0050729

GO:0050886

GO:0050896

GO:0051247

GO:0055065

GO:0060089

GO:0060326

GO:0086097

GO:0097746

GO:1903589

GO:1905920

GO:2000379

HMNXSV003038674

ILMN_1814327

ILMN_2341343

PH_hs_0029031

S77410_at

g4757729_3p_a_at

g6715581_3p_a_at

Participates

as a candidate of

ARRB-binding GPCRs [plasma membrane] (Homo sapiens)

as an input of

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

Other forms of this molecule

AGTR1 [clathrin-coated endocytic vesicle membrane]

Inferred To

Tre1 [plasma membrane] (Drosophila melanogaster)

moody [plasma membrane] (Drosophila melanogaster)

AGTR1 [plasma membrane] (Bos taurus)

AGTR1 [plasma membrane] (Canis familiaris)

AGTR1 [plasma membrane] (Gallus gallus)

AGTR1 [plasma membrane] (Mus musculus)

AGTR1 [plasma membrane] (Rattus norvegicus)

AGTR1 [plasma membrane] (Sus scrofa)

agtr1b [plasma membrane] (Danio rerio)

npr-25 [plasma membrane] (Caenorhabditis elegans)

Homologues of AGTR1 [plasma membrane] (Drosophila melanogaster)

EG:22E5.10 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_033611.1, NP_000676.1, NP_114438.2, NP_004826.5, NP_114038.4

ZINC - World Drugs

AGTR1_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000144891

ZINC - FDA approved

AGTR1_HUMAN

ZINC - Substances

AGTR1_HUMAN

ZINC target

P30556

ZINC - Biogenic

AGTR1_HUMAN

PRO

P30556

PDB

6OS2, 4ZUD, 6OS1, 6DO1, 6OS0, 4YAY

ZINC - Investigational

AGTR1_HUMAN

ZINC - Metabolites

AGTR1_HUMAN

GeneCards

P30556

HPA

ENSG00000144891-AGTR1

Ensembl

ENSP00000398832, ENST00000475347, ENST00000474935, ENSP00000418084, ENST00000349243, ENST00000497524, ENST00000418473, ENSP00000418851, ENST00000402260, ENSP00000419783, ENSP00000273430, ENSP00000419422, ENSP00000385641, ENST00000461609, ENST00000404754, ENSP00000385612, ENSG00000144891

Pharos - Targets

P30556

ZINC - Predictions - Purchasable

AGTR1_HUMAN

Orphanet

16808

HMDB Protein

HMDBP02164

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.713	14
UniProt:P48029 SLC6A8	1	SLC6A8 [plasma membrane] (R-HSA-200393)	0.527	2
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.527	2
UniProt:P54368 OAZ1	1	OAZ1 [cytosol] (R-HSA-350587)	0.508	2
UniProt:P05026 ATP1B1	1	ATP1B1 [plasma membrane] (R-HSA-375071)	0.508	2
UniProt:Q6ZMG9 CERS6	1	CERS6 [endoplasmic reticulum membrane] (R-HSA-428145)	0.508	2
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.508	2

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