Reactome | SEMA4D interacts with CD72

SEMA4D interacts with CD72

Stable Identifier

R-HSA-373748

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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In the immune system, Sema4D/CD100 binds CD72 to mediate B-cell-B-cell, B-cell-T-cell and T-cell-dendritic cell interactions and there by regulates B-cell and T-cell activation. In B-cells, this interaction directs the dissociation of SHP-1 from the CD72 cytoplasmic domain and enhances their activation.

Literature References

PubMed ID	Title	Journal	Year
12882840	Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses Akahani, S, Kumanogoh, A, Kikutani, H, Noda, K, Ishida, I, Suzuki, K	Int Immunol	2003
11114375	Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling Uchida, J, Iwahori, K, Yakura, H, Yoshida, K, Parnes, JR, Pan, C, Hirata, H, Araki, H, Yasui, T, Shi, W, Lee, I, Matsumoto, M, Kumanogoh, A, Kikutani, H, Wang, X, Watanabe, C	Immunity	2000