SEMA4D interacts with CD72

Stable Identifier
Reaction [binding]
Homo sapiens
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In the immune system, Sema4D/CD100 binds CD72 to mediate B-cell-B-cell, B-cell-T-cell and T-cell-dendritic cell interactions and there by regulates B-cell and T-cell activation. In B-cells, this interaction directs the dissociation of SHP-1 from the CD72 cytoplasmic domain and enhances their activation.

Literature References
PubMed ID Title Journal Year
11114375 Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling

Kumanogoh, A, Watanabe, C, Lee, I, Wang, X, Shi, W, Araki, H, Hirata, H, Iwahori, K, Uchida, J, Yasui, T, Matsumoto, M, Yoshida, K, Yakura, H, Pan, C, Parnes, JR, Kikutani, H

Immunity 2000
12882840 Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses

Ishida, I, Kumanogoh, A, Suzuki, K, Akahani, S, Noda, K, Kikutani, H

Int Immunol 2003
Participant Of
Orthologous Events
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