In the immune system, Sema4D/CD100 binds CD72 to mediate B-cell-B-cell, B-cell-T-cell and T-cell-dendritic cell interactions and there by regulates B-cell and T-cell activation. In B-cells, this interaction directs the dissociation of SHP-1 from the CD72 cytoplasmic domain and enhances their activation.
Akahani, S, Kumanogoh, A, Kikutani, H, Noda, K, Ishida, I, Suzuki, K
Uchida, J, Iwahori, K, Yakura, H, Yoshida, K, Parnes, JR, Pan, C, Hirata, H, Araki, H, Yasui, T, Shi, W, Lee, I, Matsumoto, M, Kumanogoh, A, Kikutani, H, Wang, X, Watanabe, C
© 2023 Reactome
