In the immune system, Sema4D/CD100 binds CD72 to mediate B-cell-B-cell, B-cell-T-cell and T-cell-dendritic cell interactions and there by regulates B-cell and T-cell activation. In B-cells, this interaction directs the dissociation of SHP-1 from the CD72 cytoplasmic domain and enhances their activation.
Kumanogoh, A, Watanabe, C, Lee, I, Wang, X, Shi, W, Araki, H, Hirata, H, Iwahori, K, Uchida, J, Yasui, T, Matsumoto, M, Yoshida, K, Yakura, H, Pan, C, Parnes, JR, Kikutani, H
Ishida, I, Kumanogoh, A, Suzuki, K, Akahani, S, Noda, K, Kikutani, H
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