Reactome | SDK2 homophillic interaction

SDK2 homophillic interaction

Stable Identifier

R-HSA-373741

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SDK1 and SDK2 are homophilic adhesion molecules. Cells expressing them exhibit a strong preference to interact exclusively with cells expressing the same sidekick form. The N-terminal four Ig domains are arranged in a horseshoe conformation and mediate homophilic adhesion, with Ig1-2 conferring the majority of binding affinity and differential specificity.

Literature References

PubMed ID	Title	Journal	Year
12230981	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina Weiner, JA, Sanes, JR, Yamagata, M	Cell	2002
17307840	The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy Ashby, JR, Kaufman, L, Klotman, ME, Klotman, PE, Huang, L, Hayashi, K, Ross, MJ, Yang, G	FASEB J	2007