Reactome | Nephrin binds NCK

Nephrin binds NCK

Stable Identifier

R-HSA-373724

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Nephrin tyrosine phosphorylation regulates podocyte cell morphology via NCK adaptor proteins. NCK via its SH2 domain interacts with the three phosphotyrosines (1176, 1193 and 1217) on nephrin, and through its SH3 domain can recruit several other proteins involved in the regulation of the actin cytoskeleton such as N WASP, WIP, ARP2/3 and PAK to the slit diaphragm. The importance of this mechanism is the maintenance of the filtration barrier. When rapid actin polymerization and cytoskeletal reorganization is needed, for example during development or injury and repair, the level of nephrin phosphorylation increases and leads to recruitment of NCK and its downstream effectors to the cytoplasmic side of the slit diaphragm.

Literature References

PubMed ID	Title	Journal	Year
16525419	Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes Jones, N, Blasutig, IM, Eremina, V, Ruston, JM, Bladt, F, Li, H, Huang, H, Larose, L, Li, SS, Takano, T, Quaggin, SE, Pawson, T	Nature	2006
16630808	Nck links nephrin to actin in kidney podocytes Tryggvason, K, Pikkarainen, T, Patrakka, J	Cell	2006
19443634	Nck proteins maintain the adult glomerular filtration barrier Jones, N, New, LA, Fortino, MA, Eremina, V, Ruston, J, Blasutig, IM, Aoudjit, L, Zou, Y, Liu, X, Yu, GL, Takano, T, Quaggin, SE, Pawson, T	J Am Soc Nephrol	2009