Reactome | Cis-Heterodimerization of nephrin and KIRREL

Cis-Heterodimerization of nephrin and KIRREL

Stable Identifier

R-HSA-373714

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Cis-Heterodimerization of nephrin and KIRREL

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Nephrin (NPHS1) forms heterodimers with KIRREL (NEPH1) molecules in a cis-configuration within the slit diaphram (SD). This heterologous protein protein interaction seems to be an important factor in maintaining the normal permeability characteristics of the slit diaphragm by relaying signals from the extracellular side into the podocyte. NPHS1:KIRREL heterodimer formation is highly conserved from C.elegans to human and serves different functions in different species and different tissues.

Literature References

PubMed ID	Title	Journal	Year
17923684	Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization Garg, P, Verma, R, Nihalani, D, Johnstone, DB, Holzman, LB	Mol Cell Biol	2007
12865409	Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability Liu, G, Kaw, B, Kurfis, J, Rahmanuddin, S, Kanwar, YS, Chugh, SS	J Clin Invest	2003
20233749	A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis Neumann-Haefelin, E, Kramer-Zucker, A, Slanchev, K, Hartleben, B, Noutsou, F, Martin, K, Wanner, N, Ritter, A, Gödel, M, Pagel, P, Fu, X, Müller, A, Baumeister, R, Walz, G, Huber, TB	Hum Mol Genet	2010
12660326	Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1 Gerke, P, Huber, TB, Sellin, L, Benzing, T, Walz, G	J Am Soc Nephrol	2003