Cis-Heterodimerization of nephrin and KIRREL

Stable Identifier
Reaction [binding]
Homo sapiens
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Nephrin (NPHS1) forms heterodimers with KIRREL (NEPH1) molecules in a cis-configuration within the slit diaphram (SD). This heterologous protein protein interaction seems to be an important factor in maintaining the normal permeability characteristics of the slit diaphragm by relaying signals from the extracellular side into the podocyte. NPHS1:KIRREL heterodimer formation is highly conserved from C.elegans to human and serves different functions in different species and different tissues.

Literature References
PubMed ID Title Journal Year
12865409 Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

Liu, G, Kaw, B, Kurfis, J, Rahmanuddin, S, Kanwar, YS, Chugh, SS

J Clin Invest 2003
17923684 Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization

Garg, P, Verma, R, Nihalani, D, Johnstone, DB, Holzman, LB

Mol Cell Biol 2007
20233749 A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis

Neumann-Haefelin, E, Kramer-Zucker, A, Slanchev, K, Hartleben, B, Noutsou, F, Martin, K, Wanner, N, Ritter, A, Gödel, M, Pagel, P, Fu, X, Müller, A, Baumeister, R, Walz, G, Huber, TB

Hum Mol Genet 2010
12660326 Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

Gerke, P, Huber, TB, Sellin, L, Benzing, T, Walz, G

J Am Soc Nephrol 2003
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