Contactin-1 (CNTN1) binds NOTCH1

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Contactin-1 (CNTN1) is composed of six Ig domains followed by four FNIII repeats and is anchored to the membrane via a glycosyl-phosphatidylinositol (GPI) tail. It is expressed transiently during CNS and PNS development both as GPI-anchored and soluble forms. CNTN1 is a physiological ligand of NOTCH, shown to bind and activate NOTCH1 and NOTCH2 in trans. The activation of NOTCH signaling by CNTN1 is Deltex (DTX)-dependent and promotes oligodendrocyte maturation and myelination.

Literature References
PubMed ID Title Journal Year
14567914 F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

Hu, QD, Ang, BT, Karsak, M, Hu, WP, Cui, XY, Duka, T, Takeda, Y, Chia, W, Sankar, N, Ng, YK, Ling, EA, Maciag, T, Small, D, Trifonova, R, Kopan, R, Okano, H, Nakafuku, M, Chiba, S, Hirai, H, Aster, JC, Schachner, M, Pallen, CJ, Watanabe, K, Xiao, ZC

Cell 2003
Participant Of
Inferred From
Cite Us!