Caspase-9 binds DCC:DIP13alpha complex

Stable Identifier
R-HSA-373700
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The ADD domain of DCC complexed with DIP13alpha interacts with the initiator caspase-9, leading to caspase activation and caspase-dependent cell death. DIP13alpha appears to function as a required adaptor to mediate DCC-caspase-9 interaction.

Literature References
PubMed ID Title Journal Year
11248093 The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

Forcet, C, Ye, X, Granger, L, Corset, V, Shin, H, Bredesen, DE, Mehlen, P

Proc Natl Acad Sci U S A 2001
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha

Liu, J, Yao, F, Wu, R, Morgan, M, Thorburn, A, Finley RL, Jr, Chen, YQ

J Biol Chem 2002
Participants
Participant Of
Orthologous Events
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