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XCL1 [extracellular region]
Stable Identifier
R-HSA-373360
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Lymphotactin, XCL1_HUMAN, SCM1-alpha
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCL1,XCL2 [extracellular region] (Homo sapiens)
XCL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47992 XCL1
Gene Names
XCL1, LTN, SCYC1
Chain
signal peptide:1-21, chain:22-114
Reference Genes
BioGPS Gene:6375 XCL1
COSMIC (genes):XCL1 XCL1
CTD Gene:6375 XCL1
dbSNP Gene:6375 XCL1
ENSEMBL:ENSG00000143184 XCL1
HGNC:10645 XCL1
KEGG:hsa:6375 XCL1
Monarch:6375 XCL1
NCBI Gene:6375 XCL1
OMIM:600250 XCL1
UCSC:P47992 XCL1
Reference Transcript
RefSeq:NM_002995.2 XCL1
RefSeq:XM_011509865.2 XCL1
Other Identifiers
11735394_s_at
11736722_at
206365_PM_at
206365_at
206366_PM_x_at
206366_x_at
214567_PM_s_at
214567_s_at
2366296
2366297
2366301
2366302
2366304
2366305
2366306
2366307
2443024
2443026
2443027
2443028
2443033
2443034
31496_g_at
39652_at
6375
7907156
8180348
A_24_P45476
D43768_at
GE56097
GO:0001916
GO:0002376
GO:0002690
GO:0002725
GO:0002726
GO:0002826
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006355
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0007267
GO:0008009
GO:0009615
GO:0010820
GO:0023052
GO:0030335
GO:0030593
GO:0032689
GO:0032703
GO:0032733
GO:0035782
GO:0042379
GO:0042803
GO:0043433
GO:0045892
GO:0048018
GO:0048020
GO:0048245
GO:0048870
GO:0050727
GO:0051209
GO:0051281
GO:0055085
GO:0061844
GO:0070098
GO:0071353
GO:0071560
GO:0071636
GO:0071663
GO:0090023
GO:0098542
GO:0098772
GO:2000412
GO:2000503
GO:2000513
GO:2000518
GO:2000538
GO:2000553
GO:2000556
GO:2000558
GO:2000562
GO:2000563
GO:2000566
HMNXSV003047326
Hs.174228.0.S1_3p_s_at
ILMN_1666257
ILMN_1718792
ILMN_2224955
PH_hs_0034104
TC01001469.hg
TC01003490.hg
g4506852_3p_at
Participates
as a member of
XCL1,XCL2 [extracellular region] (Homo sapiens)
Inferred To
XCL1 [extracellular region]
(Sus scrofa)
Homologues of XCL2 [extracellular region]
(Gallus gallus)
CCL26 [extracellular region]
(Gallus gallus)
CCLi7 [extracellular region]
(Gallus gallus)
CCLi8 [extracellular region]
(Gallus gallus)
Xcl1 [extracellular region]
(Mus musculus)
Xcl1 [extracellular region]
(Rattus norvegicus)
CCL4 [extracellular region]
(Gallus gallus)
CX3CL1 [extracellular region]
(Gallus gallus)
CCLi9 [extracellular region]
(Gallus gallus)
XCL2 [extracellular region]
(Bos taurus)
XCL2 [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_002986.1
,
XP_011508167.1
ENSEMBL
ENSG00000143184
,
ENST00000367818
,
ENSP00000356792
OpenTargets
ENSG00000143184
GeneCards
XCL1
HPA
ENSG00000143184-XCL1
PRO
P47992
Pharos - Targets
P47992
GlyGen
P47992
PDB
2HDM
,
1J9O
,
2NYZ
,
2N54
,
1J8I
,
2JP1
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
3
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