Reactome | XCL1 [extracellular region]

XCL1 [extracellular region]

Stable Identifier

R-HSA-373360

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Lymphotactin, XCL1_HUMAN, SCM1-alpha

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)
        
        XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
        
        XCL1,XCL2 [extracellular region] (Homo sapiens)
        
        XCL1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P47992 XCL1

Gene Names

XCL1, LTN, SCYC1

Chain

signal peptide:1-21, chain:22-114

Reference Genes

BioGPS Gene:6375 XCL1

COSMIC (genes):XCL1 XCL1

CTD Gene:6375 XCL1

dbSNP Gene:6375 XCL1

ENSEMBL:ENSG00000143184 XCL1

HGNC:10645 XCL1

KEGG Gene (Homo sapiens):6375 XCL1

Monarch:6375 XCL1

NCBI Gene:6375 XCL1

OMIM:600250 XCL1

UCSC:P47992 XCL1

Reference Transcript

Other Identifiers

0005270273

11735394_s_at

11736722_at

206365_at

206366_x_at

214567_s_at

2366296

2366297

2366301

2366302

2366304

2366305

2366306

2366307

2443024

2443026

2443027

2443028

2443033

2443034

31496_g_at

39652_at

6375

7907156

8180348

A_24_P45476

D43768_at

GE56097

GO:0001916

GO:0002376

GO:0002548

GO:0002690

GO:0002725

GO:0002726

GO:0002826

GO:0003674

GO:0005125

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005623

GO:0006464

GO:0006810

GO:0006935

GO:0006950

GO:0006954

GO:0006955

GO:0007155

GO:0007165

GO:0007186

GO:0007267

GO:0008009

GO:0008150

GO:0008283

GO:0009058

GO:0009615

GO:0010820

GO:0030593

GO:0032689

GO:0032703

GO:0032733

GO:0034641

GO:0035782

GO:0040011

GO:0042379

GO:0042592

GO:0042803

GO:0043433

GO:0043547

GO:0045892

GO:0048020

GO:0048245

GO:0048247

GO:0048870

GO:0050727

GO:0051209

GO:0051281

GO:0055085

GO:0070098

GO:0070374

GO:0071346

GO:0071347

GO:0071353

GO:0071356

GO:0071560

GO:0071636

GO:0071663

GO:0090023

GO:2000412

GO:2000503

GO:2000513

GO:2000518

GO:2000538

GO:2000553

GO:2000556

GO:2000558

GO:2000562

GO:2000563

GO:2000566

Hs.174228.0.S1_3p_s_at

ILMN_1666257

ILMN_1718792

ILMN_2224955

PH_hs_0034104

TC01001469.hg

TC01003490.hg

g4506852_3p_at

Participant Of

hasMember

XCL1,XCL2 [extracellular region]

Inferred To

LOC101884623 [extracellular region] (Danio rerio)

ccl39.5 [extracellular region] (Danio rerio)

ccl39.6 [extracellular region] (Danio rerio)

Xcl1 [extracellular region] (Mus musculus)

Xcl1 [extracellular region] (Rattus norvegicus)

ccl33.3 [extracellular region] (Danio rerio)

ccl25a [extracellular region] (Danio rerio)

cxcl32b.1 [extracellular region] (Danio rerio)

CCL20 [extracellular region] (Gallus gallus)

ccl20a.3 [extracellular region] (Danio rerio)

XCL1 [extracellular region] (Gallus gallus)

XCL1 [extracellular region] (Sus scrofa)

Homologues of XCL2 [extracellular region] (Danio rerio)

Homologues of XCL2 [extracellular region] (Gallus gallus)

LOC101884175 [extracellular region] (Danio rerio)

ccl25b [extracellular region] (Danio rerio)

ccl39.2 [extracellular region] (Danio rerio)

ccl39.1 [extracellular region] (Danio rerio)

ccl33.2 [extracellular region] (Danio rerio)

ccl39.3 [extracellular region] (Danio rerio)

ccl39.4 [extracellular region] (Danio rerio)

ccl39a.10 [extracellular region] (Danio rerio)

ccl44 [extracellular region] (Danio rerio)

XCL2 [extracellular region] (Bos taurus)

XCL2 [extracellular region] (Canis familiaris)

XCL2 [extracellular region] (Danio rerio)

ccl34b.4 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_002986.1, XP_011508167.1

OpenTargets

ENSG00000143184

HPA

ENSG00000143184-XCL1

GeneCards

P47992

Ensembl

ENSP00000356792, ENSG00000143184, ENST00000367818

PRO

P47992

PDB

2HDM, 2NYZ, 1J9O, 2N54, 2JP1, 1J8I

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	3
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	2