Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta

Stable Identifier
R-HSA-373339
Type
Reaction [binding]
Species
Homo sapiens
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Single C motif-1 (SCM-1; lymphotactin, CXC1) is a member of the chemokine receptor family (Yoshida T et al, 1995). CXC differs from the CC chemokines by one amino acid separating two of the four conserved cysteine residues (to give the motif CXC) whereas two adjacent cysteines denote CC. In humans, there are two highly conserved SCM-1 genes, SCYC1 and 2, which encode two SCM-1 proteins, SCM1-alpha and beta (Yoshida T et al, 1996). These proteins act as specific ligands for the CXC1 receptor. This receptor is highly expressed in placenta but lowly in spleen and thymus.

Literature References
PubMed ID Title Journal Year
7875320 Molecular cloning of a novel C or gamma type chemokine, SCM-1

Yoshida, T, Imai, T, Kakizaki, M, Nishimura, M, Yoshie, O

FEBS Lett 1995
8849694 Structure and expression of two highly related genes encoding SCM-1/human lymphotactin

Yoshida, T, Imai, T, Takagi, S, Nishimura, M, Ishikawa, I, Yaoi, T, Yoshie, O

FEBS Lett 1996
7602097 Molecular cloning and functional characterization of human lymphotactin

Kennedy, J, Kelner, GS, Kleyensteuber, S, Schall, TJ, Weiss, MC, Yssel, H, Schneider, PV, Cocks, BG, Bacon, KB, Zlotnik, A

J Immunol 1995
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