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CCL21 [extracellular region]
Stable Identifier
R-HSA-373116
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C-C motif chemokine 21, CCL21_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CCR11 binds CCL19, CCL21 & CCL25 (Homo sapiens)
CCL19, CCL21, CCL25 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
CCR11:CCL19,21,25 [plasma membrane] (Homo sapiens)
CCL19, CCL21, CCL25 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
CCR7:CCL19,21 [plasma membrane] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
CCL21 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00585 CCL21
Gene Names
CCL21, SCYA21, UNQ784/PRO1600
Chain
signal peptide:1-23, chain:24-134
Reference Genes
BioGPS Gene:6366 CCL21
COSMIC (genes):CCL21 CCL21
CTD Gene:6366 CCL21
dbSNP Gene:6366 CCL21
ENSEMBL:ENSG00000137077.8 CCL21
HGNC:10620 CCL21
KEGG Gene (Homo sapiens):6366 CCL21
Monarch:6366 CCL21
NCBI Gene:6366 CCL21
OMIM:602737 CCL21
UCSC:O00585 CCL21
Reference Transcript
RefSeq:NM_002989.3 CCL21
Other Identifiers
0003130372
11717853_at
17093543
204606_PM_at
204606_at
3204302
3204303
3204304
3204306
3204307
3204308
3204309
36503_at
6366
8160889
AB002409_at
A_23_P112470
A_33_P3273623
A_33_P3285945
GE53102
GO:0001768
GO:0001771
GO:0001954
GO:0002376
GO:0002407
GO:0002548
GO:0002606
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006629
GO:0006935
GO:0006954
GO:0006955
GO:0007010
GO:0007155
GO:0007163
GO:0007165
GO:0007186
GO:0007267
GO:0008009
GO:0010560
GO:0010820
GO:0012501
GO:0016192
GO:0016477
GO:0023052
GO:0030154
GO:0030593
GO:0030838
GO:0031274
GO:0031295
GO:0031529
GO:0031732
GO:0033630
GO:0034695
GO:0035759
GO:0036211
GO:0038116
GO:0042379
GO:0043123
GO:0043547
GO:0043552
GO:0045860
GO:0046330
GO:0048020
GO:0048245
GO:0048247
GO:0048260
GO:0048469
GO:0048856
GO:0048870
GO:0050921
GO:0051209
GO:0051491
GO:0051897
GO:0055065
GO:0055085
GO:0060326
GO:0065003
GO:0070098
GO:0070374
GO:0071346
GO:0071347
GO:0071356
GO:0090023
GO:0090630
GO:0097026
GO:0098542
GO:0098772
GO:1901135
GO:1903237
GO:1990869
GO:2000147
GO:2000406
GO:2000529
GO:2000548
GO:2000669
HMNXSV003034983
ILMN_1677505
PH_hs_0003717
TC09001045.hg
g4506834_3p_at
g4506834_3p_x_at
Participates
as a member of
CCL19, CCL21, CCL25 [extracellular region] (Homo sapiens)
CCL19,21 [extracellular region] (Homo sapiens)
Inferred To
Ccl21 [extracellular region]
(Rattus norvegicus)
Ccl21a [extracellular region]
(Mus musculus)
Ccl21b [extracellular region]
(Mus musculus)
Homologues of CCL21 [extracellular region]
(Mus musculus)
CCL21 [extracellular region]
(Bos taurus)
CCL21 [extracellular region]
(Danio rerio)
CCL21 [extracellular region]
(Sus scrofa)
LOC100857191 [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_002980.1
OpenTargets
ENSG00000137077
GeneCards
O00585
HPA
ENSG00000137077-CCL21
Ensembl
ENST00000259607
,
ENSG00000137077
,
ENSP00000259607
PRO
O00585
Pharos - Targets
O00585
PDB
2L4N
,
5EKI
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
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