Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CCL16 [extracellular region]
Stable Identifier
R-HSA-373103
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C-C motif chemokine 16, CCL16_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCL16 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15467 CCL16
Gene Names
CCL16, ILINCK, NCC4, SCYA16
Chain
signal peptide:1-23, chain:24-120
Reference Genes
BioGPS Gene:6360 CCL16
CTD Gene:6360 CCL16
dbSNP Gene:6360 CCL16
ENSEMBL:ENSG00000275152 CCL16
HGNC:10614 CCL16
KEGG:hsa:6360 CCL16
Monarch:6360 CCL16
NCBI Gene:6360 CCL16
OMIM:601394 CCL16
UCSC:O15467 CCL16
Reference Transcript
RefSeq:NM_004590.3 CCL16
RefSeq:XM_005258020.4 CCL16
Other Identifiers
11732829_at
16843541
207354_PM_at
207354_at
34434_at
3753957
3753958
3753959
3753960
3753961
3753962
3753963
3753964
3753965
6360
8014342
A_23_P207582
A_33_P3292478
GE81415
GO:0002376
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006954
GO:0006955
GO:0007154
GO:0007165
GO:0007267
GO:0008009
GO:0023052
GO:0030335
GO:0042056
GO:0048018
GO:0048020
GO:0048245
GO:0048870
GO:0050918
GO:0060326
GO:0061844
GO:0070098
GO:0098542
GO:0098772
HMNXSV003031724
HMNXSV003032168
ILMN_2045324
PH_hs_0001055
TC17001382.hg
g4759073_3p_at
Participates
as an input of
Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)
as a component of
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
Inferred To
CCL26 [extracellular region]
(Gallus gallus)
CCLi7 [extracellular region]
(Gallus gallus)
CCLi8 [extracellular region]
(Gallus gallus)
Homologues of CCL16 [extracellular region]
(Gallus gallus)
CCL4 [extracellular region]
(Gallus gallus)
CX3CL1 [extracellular region]
(Gallus gallus)
CCLi9 [extracellular region]
(Gallus gallus)
CCL16 [extracellular region]
(Bos taurus)
CCL16 [extracellular region]
(Gallus gallus)
CCL16 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
XP_005258077.1
,
NP_004581.1
ENSEMBL
ENST00000621559
,
ENSP00000478024
,
ENSP00000482168
,
ENST00000611905
OpenTargets
ENSG00000275152
HPA
ENSG00000275152-CCL16
PRO
O15467
Pharos - Targets
O15467
HMDB Protein
HMDBP07571
PDB
7SCT
,
8FK9
,
5LTL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text