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CCR4 [plasma membrane]
Stable Identifier
R-HSA-373090
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-C chemokine receptor type 4, CCR4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
CCR3,4,5 [plasma membrane] (Homo sapiens)
CCR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51679 CCR4
Gene Names
CCR4, CMKBR4
Chain
chain:1-360
Reference Genes
BioGPS Gene:1233 CCR4
COSMIC (genes):CCR4 CCR4
CTD Gene:1233 CCR4
dbSNP Gene:1233 CCR4
ENSEMBL:ENSG00000183813 CCR4
HGNC:1605 CCR4
KEGG:hsa:1233 CCR4
Monarch:1233 CCR4
NCBI Gene:1233 CCR4
OMIM:604836 CCR4
UCSC:P51679 CCR4
Reference Transcript
RefSeq:NM_005508.4 CCR4
RefSeq:XM_017005687.1 CCR4
Other Identifiers
11736720_at
11759215_at
1233
16938707
208376_PM_at
208376_at
2616132
2616134
2616135
2616136
2616137
2616138
2616139
2616140
390_at
8078442
A_14_P115503
A_23_P72989
GE80336
GO:0001764
GO:0002376
GO:0002507
GO:0004930
GO:0004950
GO:0005515
GO:0005886
GO:0006935
GO:0006954
GO:0006955
GO:0007186
GO:0007204
GO:0009617
GO:0009897
GO:0016020
GO:0016493
GO:0019722
GO:0019957
GO:0043025
GO:0048870
GO:0048872
GO:0050927
GO:0060089
GO:0060326
GO:0070098
GO:1904936
HMNXSV003005613
ILMN_2086143
PH_hs_0032055
TC03000164.hg
X85740_at
g5031626_3p_at
Participates
as a member of
CCR3,4,5 [plasma membrane] (Homo sapiens)
Inferred To
CCR4 [plasma membrane]
(Bos taurus)
CCR4 [plasma membrane]
(Gallus gallus)
CCR4 [plasma membrane]
(Sus scrofa)
Ccr4 [plasma membrane]
(Mus musculus)
Ccr4 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_005499.1
,
XP_016861176.1
Guide to Pharmacology - Targets
61
ENSEMBL
ENSG00000183813
,
ENST00000330953
,
ENSP00000332659
OpenTargets
ENSG00000183813
ZINC - FDA approved
CCR4_HUMAN
ZINC - Substances
CCR4_HUMAN
ZINC - Biogenic
CCR4_HUMAN
ZINC target
P51679
PRO
P51679
GlyGen
P51679
ZINC - Investigational
CCR4_HUMAN
ZINC - Metabolites
CCR4_HUMAN
GeneCards
CCR4
HPA
ENSG00000183813-CCR4
Pharos - Targets
P51679
ZINC - Predictions - Purchasable
CCR4_HUMAN
HMDB Protein
HMDBP07577
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