Receptor CCR10 binds CCL27 and 28 ligands

Stable Identifier
R-HSA-373086
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CCR10 (previously known as GPR2) (Jarmin DI et al, 2000) is implicated in skin inflammation and recruits regulatory T cells to mucosal layers. CCR10 binds both CCL27 (ESkine, CTACK) (Homey B et al, 2000) and CCL28 (Mucosae-associated epithelial chemokine, MEC) (Wang W et al, 2000) and signal transduction is via increase of intracellular calcium levels.

Literature References
PubMed ID Title Journal Year
10725697 Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)

Homey, B, Wang, W, Soto, H, Buchanan, ME, Wiesenborn, A, Catron, D, Müller, A, McClanahan, TK, Dieu-Nosjean, MC, Orozco, R, Ruzicka, T, Lehmann, P, Oldham, E, Zlotnik, A

J Immunol 2000
10725696 Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine

Jarmin, DI, Rits, M, Bota, D, Gerard, NP, Graham, GJ, Clark-Lewis, I, Gerard, C

J Immunol 2000
10781587 Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)

Wang, W, Soto, H, Oldham, ER, Buchanan, ME, Homey, B, Catron, D, Jenkins, N, Copeland, NG, Gilbert, DJ, Nguyen, N, Abrams, J, Kershenovich, D, Smith, K, McClanahan, T, Vicari, AP, Zlotnik, A

J Biol Chem 2000
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