Reactome | Receptor CCR10 binds CCL27 and 28 ligands

Receptor CCR10 binds CCL27 and 28 ligands

Stable Identifier

R-HSA-373086

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)

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Receptor CCR10 binds CCL27 and 28 ligands

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CCR10 (previously known as GPR2) (Jarmin DI et al, 2000) is implicated in skin inflammation and recruits regulatory T cells to mucosal layers. CCR10 binds both CCL27 (ESkine, CTACK) (Homey B et al, 2000) and CCL28 (Mucosae-associated epithelial chemokine, MEC) (Wang W et al, 2000) and signal transduction is via increase of intracellular calcium levels.

Literature References

PubMed ID	Title	Journal	Year
10725696	Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine Rits, M, Bota, D, Gerard, C, Graham, GJ, Clark-Lewis, I, Jarmin, DI, Gerard, NP	J Immunol	2000
10725697	Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC) Wiesenborn, A, Ruzicka, T, Soto, H, Lehmann, P, Buchanan, ME, Wang, W, Homey, B, Müller, A, Zlotnik, A, Orozco, R, Catron, D, Oldham, E, Dieu-Nosjean, MC, McClanahan, TK	J Immunol	2000
10781587	Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2) Jenkins, N, Vicari, AP, Smith, K, Soto, H, Buchanan, ME, Gilbert, DJ, Homey, B, Wang, W, Copeland, NG, Nguyen, N, Zlotnik, A, McClanahan, T, Kershenovich, D, Catron, D, Oldham, ER, Abrams, J	J Biol Chem	2000