Metabotropic glutamate receptors bind glutamate

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Homo sapiens
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The metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors (GPCRs) (Pin JP et al, 1995; Conn PJ and Pin JP, 1997). Metabotropic glutamate receptors are characterized by a large N-terminal extracellular domain of approximately 560 amino acids which possesses the glutamate binding domain and confers selectivity for agonists. There are eight mGluRs, 1-8 (Desai MA et al, 1995; Flor PJ et al, 1995; Emile L. et al, 1996; Flor PJ et al, 1995b; Minakami R et al, 1994; Laurie DJ et al, 1997; Wu S et al, 1998 respectively). They can be subdivided into 'groups' according to their sequence homology, signal transduction mechanisms and pharmacological properties. Group I contains mGluR1 and 5; Group II contains mGluR2 and 3; Group III contains mGluR4,6,7 and 8 (Nakanishi S, 1992). Group I receptors activate PLC downstream via coupling to Gq/11. Groups II and III inhibit adenylyl cyclase via coupling to Gi.
Like all glutamate receptors, mGluRs bind to glutamate, an amino acid that functions as an excitatory neurotransmitter. Glutamate is the most abundant excitatory neurotransmitter in the mammalian nervous system.

Literature References
PubMed ID Title Journal Year
7908515 Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

Katsuki, F, Minakami, R, Sugiyama, H, Nakamura, K, Yamamoto, T

Biochem Biophys Res Commun 1994
9144651 Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor

Wiederhold, KH, Schoeffter, P, Sommer, B, Laurie, DJ

Neuropharmacology 1997
7620613 Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2

Lukic, S, Flor, PJ, Kuhn, R, Püttner, I, Knöpfel, T, Rüegg, D, Lindauer, K

Eur J Neurosci 1995
7617140 Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4

Lukic, S, Leonhardt, T, Flor, PJ, Kuhn, R, Knöpfel, T, Rüegg, D

Neuropharmacology 1995
7623957 The metabotropic glutamate receptors: structure and functions

Duvoisin, R, Pin, JP

Neuropharmacology 1995
7476890 Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter

Burnett, JP, Desai, MA, Mayne, NG, Schoepp, DD

Mol Pharmacol 1995
9131252 Pharmacology and functions of metabotropic glutamate receptors

Conn, PJ, Pin, JP

Annu Rev Pharmacol Toxicol 1997
1329206 Molecular diversity of glutamate receptors and implications for brain function

Nakanishi, S

Science 1992
8887960 Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3

Mercken, L, Emile, L, Blanchard, JC, Menager, J, Bock, MD, Doble, A, Apiou, F, Clot, J, Pradier, L

Neuropharmacology 1996
9473604 Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

Burgett, SG, Rosteck PR, Jr, Wright, RA, Arnold, JS, Belagaje, RM, Schoepp, DD, Johnson, BG, Rockey, PK, Wu, S

Brain Res Mol Brain Res 1998
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