Receptors CCR1, 2 and 8 bind CCL16 ligand

Stable Identifier
Homo sapiens
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These three receptors can all bind the CC chemokine CCL16. CCR1 was the first CC chemokine receptor identified (Neote K et al, 1993) and can bind multiple chemokines. CCR1 is found on blood lymphocytes and monocytes. CCR2 is found on monocytes, B cells, activated memory T cells and basophils (Yamagami S et al, 1994). CCR8 is found mainly in the thymus (Tiffany HL et al, 1997).

Literature References
PubMed ID Title Journal Year
9207005 Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309

Murphy, PM, Locati, M, Tiffany, HL, Combadiere, C, Gao, JL, Modi, W, Pease, J, Bonner, TI, Lautens, LL

J Exp Med 1997
8048929 cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor

Endo, N, Ishii, K, Tokuda, Y, Yamagami, S, Tanaka, H

Biochem Biophys Res Commun 1994
7679328 Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

Mak, JY, Schall, TJ, Horuk, R, DiGregorio, D, Neote, K

Cell 1993
Orthologous Events
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