These three receptors can all bind the CC chemokine CCL16. CCR1 was the first CC chemokine receptor identified (Neote K et al, 1993) and can bind multiple chemokines. CCR1 is found on blood lymphocytes and monocytes. CCR2 is found on monocytes, B cells, activated memory T cells and basophils (Yamagami S et al, 1994). CCR8 is found mainly in the thymus (Tiffany HL et al, 1997).
Yamagami, S, Tokuda, Y, Ishii, K, Tanaka, H, Endo, N
Tiffany, HL, Lautens, LL, Gao, JL, Pease, J, Locati, M, Combadiere, C, Modi, W, Bonner, TI, Murphy, PM
Neote, K, DiGregorio, D, Mak, JY, Horuk, R, Schall, TJ
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