Reactome | Receptors CCR1, 2 and 8 bind CCL16 ligand

Receptors CCR1, 2 and 8 bind CCL16 ligand

Stable Identifier

R-HSA-373073

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Receptors CCR1, 2 and 8 bind CCL16 ligand

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

These three receptors can all bind the CC chemokine CCL16. CCR1 was the first CC chemokine receptor identified (Neote K et al, 1993) and can bind multiple chemokines. CCR1 is found on blood lymphocytes and monocytes. CCR2 is found on monocytes, B cells, activated memory T cells and basophils (Yamagami S et al, 1994). CCR8 is found mainly in the thymus (Tiffany HL et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
9207005	Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309 Murphy, PM, Locati, M, Tiffany, HL, Combadiere, C, Gao, JL, Modi, W, Pease, J, Bonner, TI, Lautens, LL	J Exp Med	1997
8048929	cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor Endo, N, Ishii, K, Tokuda, Y, Yamagami, S, Tanaka, H	Biochem Biophys Res Commun	1994
7679328	Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor Mak, JY, Schall, TJ, Horuk, R, DiGregorio, D, Neote, K	Cell	1993