Receptors CCR1, 2 and 8 bind CCL16 ligand

Stable Identifier
R-HSA-373073
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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These three receptors can all bind the CC chemokine CCL16. CCR1 was the first CC chemokine receptor identified (Neote K et al, 1993) and can bind multiple chemokines. CCR1 is found on blood lymphocytes and monocytes. CCR2 is found on monocytes, B cells, activated memory T cells and basophils (Yamagami S et al, 1994). CCR8 is found mainly in the thymus (Tiffany HL et al, 1997).

Literature References
PubMed ID Title Journal Year
8048929 cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor

Yamagami, S, Tokuda, Y, Ishii, K, Tanaka, H, Endo, N

Biochem Biophys Res Commun 1994
9207005 Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309

Tiffany, HL, Lautens, LL, Gao, JL, Pease, J, Locati, M, Combadiere, C, Modi, W, Bonner, TI, Murphy, PM

J Exp Med 1997
7679328 Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

Neote, K, DiGregorio, D, Mak, JY, Horuk, R, Schall, TJ

Cell 1993
Participants
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Orthologous Events
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