Reactome | Receptors CCR1, 2 and 8 bind CCL16 ligand

Receptors CCR1, 2 and 8 bind CCL16 ligand

Stable Identifier

R-HSA-373073

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)

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Receptors CCR1, 2 and 8 bind CCL16 ligand

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These three receptors can all bind the CC chemokine CCL16. CCR1 was the first CC chemokine receptor identified (Neote K et al, 1993) and can bind multiple chemokines. CCR1 is found on blood lymphocytes and monocytes. CCR2 is found on monocytes, B cells, activated memory T cells and basophils (Yamagami S et al, 1994). CCR8 is found mainly in the thymus (Tiffany HL et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
9207005	Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309 Murphy, PM, Locati, M, Tiffany, HL, Combadiere, C, Gao, JL, Modi, W, Pease, J, Bonner, TI, Lautens, LL	J Exp Med	1997
8048929	cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor Endo, N, Ishii, K, Tokuda, Y, Yamagami, S, Tanaka, H	Biochem Biophys Res Commun	1994
7679328	Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor Mak, JY, Schall, TJ, Horuk, R, DiGregorio, D, Neote, K	Cell	1993