Reactome | Receptors CCR3, 4 and 5 bind CCL5 ligand

Receptors CCR3, 4 and 5 bind CCL5 ligand

Stable Identifier

R-HSA-373061

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)

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Receptors CCR3, 4 and 5 bind CCL5 ligand

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Three receptors have a common CC chemokine CCL5 that can signal through them. CCR3 (Combadiere C et al, 1995) is highly expressed in eosinophils and basophils and also found in airway epithelial cells, thus implicating this receptor in allergic reactions. CCR4 (Power CA et al, 1995) is expressed in Th2 T lymphocytes and upregulated by T-cell receptor activation. CCR5 (Samson M et al, 1996) mediates the recruitment of cells involved in immune and inflammatory processes.

Literature References

PubMed ID	Title	Journal	Year
8639485	Molecular cloning and functional expression of a new human CC-chemokine receptor gene Samson, M, Mollereau, C, Parmentier, M, Vassart, G, Labbe, O	Biochemistry	1996
7622448	Cloning and functional expression of a human eosinophil CC chemokine receptor Murphy, PM, Combadiere, C, Ahuja, SK	J Biol Chem	1995
7642634	Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line Power, CA, Proudfoot, AE, Wells, TN, Meyer, A, Hoogewerf, AJ, Bacon, KB, Nemeth, K	J Biol Chem	1995