Receptors CCR3, 4 and 5 bind CCL5 ligand

Stable Identifier
R-HSA-373061
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Three receptors have a common CC chemokine CCL5 that can signal through them. CCR3 (Combadiere C et al, 1995) is highly expressed in eosinophils and basophils and also found in airway epithelial cells, thus implicating this receptor in allergic reactions. CCR4 (Power CA et al, 1995) is expressed in Th2 T lymphocytes and upregulated by T-cell receptor activation. CCR5 (Samson M et al, 1996) mediates the recruitment of cells involved in immune and inflammatory processes.

Literature References
PubMed ID Title Journal Year
7622448 Cloning and functional expression of a human eosinophil CC chemokine receptor

Combadiere, C, Ahuja, SK, Murphy, PM

J Biol Chem 1995
8639485 Molecular cloning and functional expression of a new human CC-chemokine receptor gene

Samson, M, Labbe, O, Mollereau, C, Vassart, G, Parmentier, M

Biochemistry 1996
7642634 Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line

Power, CA, Meyer, A, Nemeth, K, Bacon, KB, Hoogewerf, AJ, Proudfoot, AE, Wells, TN

J Biol Chem 1995
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