Receptors CCR3, 4 and 5 bind CCL5 ligand

Stable Identifier
Homo sapiens
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Three receptors have a common CC chemokine CCL5 that can signal through them. CCR3 (Combadiere C et al, 1995) is highly expressed in eosinophils and basophils and also found in airway epithelial cells, thus implicating this receptor in allergic reactions. CCR4 (Power CA et al, 1995) is expressed in Th2 T lymphocytes and upregulated by T-cell receptor activation. CCR5 (Samson M et al, 1996) mediates the recruitment of cells involved in immune and inflammatory processes.

Literature References
PubMed ID Title Journal Year
8639485 Molecular cloning and functional expression of a new human CC-chemokine receptor gene

Samson, M, Mollereau, C, Parmentier, M, Vassart, G, Labbe, O

Biochemistry 1996
7622448 Cloning and functional expression of a human eosinophil CC chemokine receptor

Murphy, PM, Combadiere, C, Ahuja, SK

J Biol Chem 1995
7642634 Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line

Power, CA, Proudfoot, AE, Wells, TN, Meyer, A, Hoogewerf, AJ, Bacon, KB, Nemeth, K

J Biol Chem 1995
Orthologous Events
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