Reactome | PCK2 phosphorylates OA to yield PEP

PCK2 phosphorylates OA to yield PEP

Stable Identifier

R-HSA-372819

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate

ReviewStatus

5/5

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PCK2 (phosphoenolcarboxykinase), located in the mitochondrial matrix, catalyzes the physiologically irreversible reaction of oxaloacetate (OA) and GTP to form phosphoenolpyruvate (PEP), GDP, and CO2 (Modaressi et al. 1996, 1998).

Literature References

PubMed ID	Title	Journal	Year
8645161	Molecular cloning, sequencing and expression of the cDNA of the mitochondrial form of phosphoenolpyruvate carboxykinase from human liver Christ, B, Heise, T, Modaressi, S, Jungermann, K, Bratke, J, Zahn, S	Biochem J	1996
9657976	Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression Brechtel, K, Christ, B, Modaressi, S, Jungermann, K	Biochem J	1998