Reactome | PCK2 [mitochondrial matrix]

PCK2 [mitochondrial matrix]

Stable Identifier

R-HSA-372815

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Phosphoenolpyruvate carboxykinase (GTP), mitochondrial

Locations in the PathwayBrowser for interactor UniProt:P10809%20HSPD1

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External Reference Information

External Reference

UniProt:Q16822 PCK2

Gene Names

PCK2, PEPCK2

Chain

transit peptide:1-32, chain:33-640

Reference Genes

BioGPS Gene:5106 PCK2

COSMIC (genes):PCK2 PCK2

CTD Gene:5106 PCK2

dbSNP Gene:5106 PCK2

ENSEMBL:ENSG00000100889 PCK2

ENSEMBL_homo_sapiens_GENE:ENSG00000100889.12 PCK2

ENSEMBL_homo_sapiens_GENE:ENSG00000285241.2 PCK2

HGNC:8725 PCK2

KEGG Gene (Homo sapiens):5106 PCK2

Monarch:5106 PCK2

NCBI Gene:5106 PCK2

OMIM:614095 PCK2

UCSC:Q16822 PCK2

Reference Transcript

Other Identifiers

11719089_a_at

11728867_a_at

16782548

202847_PM_at

202847_at

3529509

3529510

3529511

3529512

3529513

3529514

3529515

3529517

3529518

3529519

3529520

3529521

3529522

3529525

3529528

3529531

3529532

3529537

3529539

3529541

3529542

3529543

3529544

3529545

37188_at

5106

7973530

86118_at

A_23_P140207

A_33_P3268532

GE60154

GO:0000166

GO:0003824

GO:0004611

GO:0004613

GO:0005515

GO:0005525

GO:0005739

GO:0005759

GO:0005829

GO:0005975

GO:0006090

GO:0006094

GO:0006107

GO:0006116

GO:0006629

GO:0016301

GO:0016310

GO:0016740

GO:0016829

GO:0016831

GO:0017076

GO:0019543

GO:0023052

GO:0030145

GO:0030154

GO:0032024

GO:0032496

GO:0032869

GO:0042594

GO:0043226

GO:0046327

GO:0046872

GO:0048856

GO:0070365

GO:0071333

GO:0071356

GO:0071548

GO:0071549

HMNXSV003014613

HMNXSV003043724

ILMN_1671791

ILMN_1760649

ILMN_1802699

PH_hs_0004373

TC14000157.hg

X92720_at

g4758885_3p_at

Inferred To

zgc:77867 [mitochondrial matrix] (Danio rerio)

pck-2 [mitochondrial matrix] (Caenorhabditis elegans)

PCK2 [mitochondrial matrix] (Bos taurus)

PCK2 [mitochondrial matrix] (Canis familiaris)

PCK2 [mitochondrial matrix] (Dictyostelium discoideum)

PCK2 [mitochondrial matrix] (Drosophila melanogaster)

PCK2 [mitochondrial matrix] (Gallus gallus)

PCK2 [mitochondrial matrix] (Mus musculus)

PCK2 [mitochondrial matrix] (Sus scrofa)

Pck2 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_004554.3, NP_001294983.1, NP_001278485.1, NP_001018083.2

OpenTargets

ENSG00000100889

IntEnz

4.1.1.32

HPA

ENSG00000100889-PCK2

GeneCards

Q16822

Ensembl

ENSP00000496343, ENSP00000496102, ENST00000644679, ENSG00000285241, ENSP00000441826, ENSP00000216780, ENST00000645536, ENSP00000454011, ENST00000645217, ENST00000545054, ENSP00000494919, ENSP00000494029, ENST00000216780, ENST00000561286, ENST00000396973, ENSP00000380171, ENSG00000100889, ENST00000645709

PRO

Q16822

Pharos - Targets

Q16822

Orphanet

16622

HMDB Protein

HMDBP00890

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.508	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.508	2
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.483	2

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