phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]

Stable Identifier
R-HSA-372449
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial inner membrane, mitochondrial matrix
Synonyms
Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
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phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]
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SLC25A1, in the inner mitochondrial membrane, mediates the exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate. The exchange is physiologically irreversible because of the potential of the inner mitochondrial membrane. The gene encoding human SLC25A1 has been cloned and its expression pattern has been characterized (Heisterkamp et al. 1995; Iacobazzi et al. 1997), but the biochemical details of the transport process are inferred from those worked out for the well-characterized rat system (Robinson 1971; Soling et al. 1971; Kleineke et al. 1973).

Literature References
PubMed ID Title Journal Year
8666394 Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region

Heisterkamp, N, Mulder, MP, Langeveld, A, ten Hoeve, J, Wang, Z, Roe, BA, Groffen, J

Genomics 1995
9254007 Organization and sequence of the human gene for the mitochondrial citrate transport protein

Iacobazzi, V, Lauria, G, Palmieri, F

DNA Seq 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]
Physical Entity
SLC25A1 [mitochondrial inner membrane]
Activity
tricarboxylic acid transmembrane transporter activity (0015142)
Orthologous Events
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Caenorhabditis elegans)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Canis familiaris)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Danio rerio)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Drosophila melanogaster)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Mus musculus)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Rattus norvegicus)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Saccharomyces cerevisiae)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Schizosaccharomyces pombe)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Sus scrofa)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Xenopus tropicalis)
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)
Authored
D'Eustachio, P  (2008-09-13)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-26)
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