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TP53 binds the MDM2 gene
Stable Identifier
R-HSA-3700997
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
TP53 binds the MDM2 gene (Homo sapiens)
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TP53 (p53) binds the p53 response element in the first intron of the MDM2 gene (Wu et al. 1993).
Literature References
PubMed ID
Title
Journal
Year
8319905
The p53-mdm-2 autoregulatory feedback loop
Levine, AJ
,
Olson, D
,
Bayle, JH
,
Wu, X
Genes Dev.
1993
Participants
Input
MDM2 gene [nucleoplasm]
(Homo sapiens)
p-S15,S20-TP53 Tetramer [nucleoplasm]
(Homo sapiens)
Output
p-S15,S20-TP53 Tetramer:MDM2 Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of TP53 Degradation (Homo sapiens)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2013-06-11)
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