Reactome | PRDX5 reduces peroxynitrite to nitrite using TXN2

PRDX5 reduces peroxynitrite to nitrite using TXN2

Stable Identifier

R-HSA-3697894

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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PRDX5 reduces peroxynitrite to nitrite using TXN2

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Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using TXN2 in mitochodria to yield nitrite (NO2-), water, and oxidized TXN2 (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.

Literature References

PubMed ID	Title	Journal	Year
12446202	Peroxynitrite reactions and formation in mitochondria Radi, R, Cassina, A, Hodara, R, Quijano, C, Castro, L	Free Radic. Biol. Med.	2002
15280035	Human peroxiredoxin 5 is a peroxynitrite reductase Dubuisson, M, Vander Stricht, D, Clippe, A, Etienne, F, Nauser, T, Kissner, R, Koppenol, WH, Rees, JF, Knoops, B	FEBS Lett.	2004