Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using TXN2 in mitochodria to yield nitrite (NO2-), water, and oxidized TXN2 (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.
Nauser, T, Vander Stricht, D, Etienne, F, Rees, JF, Dubuisson, M, Knoops, B, Koppenol, WH, Clippe, A, Kissner, R
Hodara, R, Cassina, A, Radi, R, Castro, L, Quijano, C
thioredoxin peroxidase activity of PRDX5-1 [mitochondrial matrix]
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