Reactome | AXIN2 [cytosol]

AXIN2 [cytosol]

Stable Identifier

R-HSA-3640821

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q96SQ5 ZNF587

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - Binding of TCF/LEF:CTNNB1 to target gene promoters (Homo sapiens)
        
        TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)
        
        AXIN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2T1 AXIN2

Gene Names

AXIN2

Chain

chain:1-843

Reference Genes

BioGPS Gene:8313 AXIN2

COSMIC (genes):AXIN2 AXIN2

CTD Gene:8313 AXIN2

dbSNP Gene:8313 AXIN2

ENSEMBL:ENSG00000168646 AXIN2

ENSEMBL_homo_sapiens_GENE:ENSG00000168646.14 AXIN2

HGNC:904 AXIN2

KEGG Gene (Homo sapiens):8313 AXIN2

Monarch:8313 AXIN2

NCBI Gene:8313 AXIN2

OMIM:604025 AXIN2

UCSC:Q9Y2T1 AXIN2

Reference Transcript

Other Identifiers

11718451_a_at

11718452_at

11718453_a_at

16847933

222695_PM_s_at

222695_s_at

222696_PM_at

222696_at

224176_PM_s_at

224176_s_at

224498_PM_x_at

224498_x_at

3767466

3767467

3767468

3767477

3767479

3767481

3767483

3767484

3767485

3767486

3767488

3767489

3767490

3767493

3767497

3767528

3767530

59763_s_at

64129_at

8017718

8313

90101_at

A_23_P148015

A_24_P298027

GE58341

GO:0001649

GO:0001756

GO:0001934

GO:0001957

GO:0003139

GO:0003180

GO:0003183

GO:0003413

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006281

GO:0008013

GO:0008104

GO:0008283

GO:0008285

GO:0009950

GO:0010718

GO:0016055

GO:0016071

GO:0019899

GO:0019901

GO:0023052

GO:0030111

GO:0030154

GO:0030163

GO:0030178

GO:0030198

GO:0030282

GO:0030877

GO:0031625

GO:0032423

GO:0032436

GO:0032991

GO:0033687

GO:0033689

GO:0036211

GO:0042476

GO:0043161

GO:0043226

GO:0043570

GO:0045600

GO:0045668

GO:0048255

GO:0048468

GO:0048545

GO:0048856

GO:0060070

GO:0060090

GO:0061181

GO:0070411

GO:0070602

GO:0071407

GO:0071549

GO:0072089

GO:0090090

GO:1903053

HMNXSV003007463

Hs.127337.0.S1_3p_a_at

Hs.127337.0.S3_3p_at

ILMN_1724480

TC17002855.hg

g13623398_3p_s_at

g6653583_3p_a_at

Participates

as an output of

TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)

as a member of

AXIN [cytosol] (Homo sapiens)

Other forms of this molecule

RibC-AXIN2 [cytosol]

Ub-RibC-AXIN2 [cytosol]

ub-AXIN2 [cytosol]

Inferred To

axin2l [cytosol] (Xenopus tropicalis)

AXIN2 [cytosol] (Bos taurus)

AXIN2 [cytosol] (Canis familiaris)

AXIN2 [cytosol] (Gallus gallus)

AXIN2 [cytosol] (Sus scrofa)

pry-1 [cytosol] (Caenorhabditis elegans)

Axin2 [cytosol] (Mus musculus)

Axin2 [cytosol] (Rattus norvegicus)

Axn [cytosol] (Drosophila melanogaster)

Homologues of AXIN2 [cytosol] (Caenorhabditis elegans)

axin2 [cytosol] (Danio rerio)

axl-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011523621.1, XP_016880681.1, NP_004646.3, XP_011523622.1, XP_011523623.1

Guide to Pharmacology - Targets

3237

OpenTargets

ENSG00000168646

ZINC - Substances

AXIN2_HUMAN

ZINC target

Q9Y2T1

PRO

Q9Y2T1

PDB

8HEO

HPA

ENSG00000168646-AXIN2

GeneCards

Q9Y2T1

Ensembl

ENST00000307078, ENSG00000168646, ENSP00000302625

Pharos - Targets

Q9Y2T1

Orphanet

15346

ZINC - Predictions - Purchasable

AXIN2_HUMAN

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.823	6
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.659	4
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.645	4
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.567	5
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.564	2
UniProt:Q8NEF3-2 CCDC112			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:O95985 TOP3B			0.556	3
UniProt:Q9BYR2 KRTAP4-5	1	KRTAP4-5 [cytosol] (R-HSA-6809950)	0.556	3
UniProt:O75638-2 CTAG2			0.556	3
UniProt:Q9UKJ5 CHIC2			0.556	3
UniProt:Q2NKX9 CB068			0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q8N3L3 TXLNB			0.556	3
UniProt:Q99728 BARD1	13	BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 C83G [nucleoplasm] (R-HSA-9699139) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775)	0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:Q15172 PPP2R5A	2	p-S28-PPP2R5A [cytosol] (R-HSA-9836658) PPP2R5A [cytosol] (R-HSA-196235)	0.556	3
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.556	3
UniProt:P60014 KRTAP10-10	1	KRTAP10-10 [cytosol] (R-HSA-6810293)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9BZW7 TSG10			0.556	3
UniProt:Q9BXS5 AP1M1	7	AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.556	3
UniProt:Q5T619 ZN648			0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.556	3
UniProt:Q8N944 AMER3			0.499	2
UniProt:Q9Y4X0 AMMR1			0.463	2

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