Reactome | UAP1 [cytosol]

UAP1 [cytosol]

Stable Identifier

R-HSA-3558428

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UDP-N-acetylhexosamine pyrophosphorylase, UAP1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
        
        GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)
        
        2xUAP1 [cytosol] (Homo sapiens)
        
        UAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16222 UAP1

Gene Names

UAP1, SPAG2

Chain

chain:1-522

Reference Genes

BioGPS Gene:6675 UAP1

COSMIC (genes):UAP1 UAP1

CTD Gene:6675 UAP1

dbSNP Gene:6675 UAP1

ENSEMBL:ENSG00000117143 UAP1

HGNC:12457 UAP1

KEGG Gene (Homo sapiens):6675 UAP1

Monarch:6675 UAP1

NCBI Gene:6675 UAP1

OMIM:602862 UAP1

UCSC:Q16222 UAP1

Reference Transcript

Other Identifiers

0004810333

11725045_a_at

16673056

209340_at

2364187

2364188

2364190

2364191

2364192

2364193

2364194

2364195

2364198

2364200

2364201

2364202

2364207

2364210

2364211

2364212

2364215

2364217

2364218

2364219

2364226

41242_at

6675

7906863

A_14_P124172

A_23_P160460

GE53245

GE874110

GO:0003674

GO:0003977

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006047

GO:0006048

GO:0008150

GO:0009058

GO:0016740

GO:0016779

GO:0030246

GO:0034641

GO:0042802

GO:0043226

GO:0044281

GO:0052630

GO:0070569

ILMN_1742461

ILMN_1888609

PH_hs_0001837

TC01001422.hg

g688010_3p_at

Participant Of

hasComponent

2xUAP1 [cytosol]

Inferred To

nrde2 [cytosol] (Xenopus tropicalis)

Uap1 [cytosol] (Mus musculus)

Uap1 [cytosol] (Rattus norvegicus)

mmy [cytosol] (Drosophila melanogaster)

UAP1 [cytosol] (Caenorhabditis elegans)

UAP1 [cytosol] (Canis familiaris)

UAP1 [cytosol] (Gallus gallus)

UAP1 [cytosol] (Plasmodium falciparum)

UAP1 [cytosol] (Sus scrofa)

uap1 [cytosol] (Danio rerio)

uap1 [cytosol] (Dictyostelium discoideum)

uap1 [cytosol] (Schizosaccharomyces pombe)

Homologues of UAP1 [cytosol] (Plasmodium falciparum)

QRI1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001311046.1, NP_001311044.1, NP_001311045.1, NP_001311043.1, XP_011508216.1, NP_003106.3, NP_001311042.1, XP_011508215.1

OpenTargets

ENSG00000117143

GeneCards

Q16222

HPA

ENSG00000117143-UAP1

Ensembl

ENST00000271469, ENSG00000117143, ENSP00000356901, ENST00000367926, ENST00000367925, ENSP00000356902, ENSP00000271469, ENSP00000356903, ENST00000367924

PRO

Q16222

PDB

1JVG, 1JVD, 1JV1, 1JV3

HMDB Protein

HMDBP01079