Reactome | UAP1 [cytosol]

UAP1 [cytosol]

Stable Identifier

R-HSA-3558428

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UDP-N-acetylhexosamine pyrophosphorylase, UAP1_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
        
        GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)
        
        2xUAP1 [cytosol] (Homo sapiens)
        
        UAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16222 UAP1

Gene Names

UAP1, SPAG2

Chain

chain:1-522

Reference Genes

BioGPS Gene:6675 UAP1

COSMIC (genes):UAP1 UAP1

CTD Gene:6675 UAP1

dbSNP Gene:6675 UAP1

ENSEMBL:ENSG00000117143 UAP1

HGNC:12457 UAP1

KEGG:hsa:6675 UAP1

Monarch:6675 UAP1

NCBI Gene:6675 UAP1

OMIM:602862 UAP1

UCSC:Q16222 UAP1

Reference Transcript

Other Identifiers

11725045_a_at

16673056

209340_PM_at

209340_at

2364190

2364191

2364192

2364193

2364194

2364195

2364198

2364200

2364201

2364202

2364207

2364208

2364209

2364210

2364211

2364212

2364214

2364215

2364217

2364218

2364219

2364226

41242_at

56125_at

6675

7906863

A_14_P124172

A_23_P160460

GE53245

GE874110

GO:0002376

GO:0003824

GO:0003977

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006048

GO:0016740

GO:0016772

GO:0016779

GO:0032481

GO:0042802

GO:0045087

GO:0052630

GO:0055086

GO:0070569

GO:0098542

GO:0140374

GO:0141090

GO:1901135

HMNXSV003002866

ILMN_1742461

ILMN_1888609

PH_hs_0001837

TC01001422.hg

g688010_3p_at

Participates

as a component of

2xUAP1 [cytosol] (Homo sapiens)

Inferred To

Uap1 [cytosol] (Mus musculus)

Uap1 [cytosol] (Rattus norvegicus)

mmy [cytosol] (Drosophila melanogaster)

UAP1 [cytosol] (Bos taurus)

UAP1 [cytosol] (Caenorhabditis elegans)

UAP1 [cytosol] (Canis familiaris)

UAP1 [cytosol] (Gallus gallus)

UAP1 [cytosol] (Plasmodium falciparum)

UAP1 [cytosol] (Sus scrofa)

uap1 [cytosol] (Danio rerio)

uap1 [cytosol] (Dictyostelium discoideum)

uap1 [cytosol] (Schizosaccharomyces pombe)

uap1 [cytosol] (Xenopus tropicalis)

Homologues of UAP1 [cytosol] (Plasmodium falciparum)

QRI1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_003106.3, XP_011508215.1, XP_054194435.1, XP_054194434.1, NP_001386719.1, NP_001386720.1, XP_047284804.1, XP_047284805.1, NP_001311044.1, NP_001375331.1, NP_001311045.1, NP_001375330.1, NP_001311046.1, XP_047284801.1, XP_047284799.1, XP_011508216.1, XP_054194437.1, XP_054194436.1, NP_001311043.1, NP_001311042.1

OpenTargets

ENSG00000117143

ENSEMBL

ENSP00000356903, ENST00000367925, ENST00000367926, ENSG00000117143, ENSP00000356902

HPA

ENSG00000117143-UAP1

GeneCards

UAP1

PRO

Q16222

Pharos - Targets

Q16222

GlyGen

Q16222

PDB

8QH2, 6Z2F, 1JV3, 1JVD, 1JV1, 1JVG

HMDB Protein

HMDBP01079

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