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CRKL [cytosol]
Stable Identifier
R-HSA-354384
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
crkL
Icon
Locations in the PathwayBrowser for interactor UniProt:P51451 BLK
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
p-FRS2 binds CRKL (Homo sapiens)
CRKL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46109 CRKL
Gene Names
CRKL
Chain
chain:1-303
Reference Genes
BioGPS Gene:1399 CRKL
COSMIC (genes):CRKL CRKL
CTD Gene:1399 CRKL
dbSNP Gene:1399 CRKL
ENSEMBL:ENSG00000099942 CRKL
ENSEMBL_homo_sapiens_GENE:ENSG00000099942.13 CRKL
HGNC:2363 CRKL
KEGG Gene (Homo sapiens):1399 CRKL
Monarch:1399 CRKL
NCBI Gene:1399 CRKL
OMIM:602007 CRKL
UCSC:P46109 CRKL
Reference Transcript
RefSeq:NM_005207.3 CRKL
Other Identifiers
11718993_at
11718994_x_at
11752708_a_at
1399
16927401
206184_PM_at
206184_at
212180_PM_at
212180_at
33524_at
35301_at
3937683
3937788
3937789
3937790
3937791
3937792
3937793
3937794
3937795
3937796
3937797
3937798
3937799
3937809
3937810
415_at
8071434
A_23_P40535
A_24_P935009
GE55439
GE59847
GO:0001558
GO:0001568
GO:0001655
GO:0001764
GO:0001783
GO:0001784
GO:0001933
GO:0001934
GO:0002376
GO:0002685
GO:0003151
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0006629
GO:0007155
GO:0007163
GO:0007165
GO:0007167
GO:0007254
GO:0007265
GO:0007283
GO:0007338
GO:0007389
GO:0007507
GO:0008284
GO:0008543
GO:0008584
GO:0009887
GO:0009952
GO:0010468
GO:0010629
GO:0012501
GO:0016358
GO:0016477
GO:0021766
GO:0021987
GO:0022414
GO:0023052
GO:0030010
GO:0030154
GO:0030971
GO:0031594
GO:0032991
GO:0033628
GO:0034330
GO:0035022
GO:0035556
GO:0035591
GO:0035685
GO:0036211
GO:0038026
GO:0042802
GO:0043226
GO:0043410
GO:0045202
GO:0045296
GO:0048384
GO:0048538
GO:0048856
GO:0048870
GO:0050773
GO:0050852
GO:0060017
GO:0060090
GO:0060326
GO:0061024
GO:0061629
GO:0070374
GO:0071466
GO:0071560
GO:0071774
GO:0086100
GO:0095500
GO:0098698
GO:0098749
GO:0098761
GO:0098890
GO:0160093
GO:1900026
GO:1903977
GO:1904393
GO:1904395
GO:1904888
GO:2000145
GO:2000404
HMNXSV003027912
HMNXSV003041118
Hs.5613.0.S1_3p_at
Hs.5613.0.S1_3p_x_at
ILMN_1690122
ILMN_1723165
PH_hs_0000573
TC22000074.hg
TC22000983.hg
X59656_at
g4885152_3p_at
Participates
as a component of
CRKL:RAPGEF1 [cytosol] (Homo sapiens)
Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
as a member of
CRK, CRKL [cytosol] (Homo sapiens)
as an input of
p-FRS2 binds CRKL (Homo sapiens)
Other forms of this molecule
p-CRKL [cytosol]
Inferred To
Ghost homologue of CRKL [cytosol]
(Gallus gallus)
Ghost homologue of CRKL [cytosol]
(Xenopus tropicalis)
Crkl [cytosol]
(Mus musculus)
Crkl [cytosol]
(Rattus norvegicus)
CRKL [cytosol]
(Bos taurus)
CRKL [cytosol]
(Canis familiaris)
CRKL [cytosol]
(Sus scrofa)
ced-2 [cytosol]
(Caenorhabditis elegans)
Crk [cytosol]
(Drosophila melanogaster)
crkl [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_005198.1
OpenTargets
ENSG00000099942
HPA
ENSG00000099942-CRKL
GeneCards
P46109
Ensembl
ENSP00000346300
,
ENST00000354336
,
ENSG00000099942
,
ENSP00000396646
,
ENST00000411769
PRO
P46109
Pharos - Targets
P46109
Orphanet
21835
PDB
2DBK
,
2BZX
,
2LQW
,
2LQN
,
2EO3
,
2BZY
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.868
9
UniProt:Q13480 GAB1
4
GAB1 [cytosol]
(R-HSA-179795)
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.753
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.749
5
UniProt:P00519 ABL1
6
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.743
4
UniProt:Q13905 RAPGEF1
2
RAPGEF1 [cytosol]
(R-HSA-913472)
RAPGEF1 [endosome]
(R-HSA-3008667)
0.723
4
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.719
4
UniProt:Q08460 Kcnma1
2
Kcnma1 [plasma membrane]
(R-MMU-9667781)
KCNMA1 [plasma membrane]
(R-MMU-418462)
0.639
5
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.621
4
UniProt:P16234 PDGFRA
20
PDGFRA L629P [plasma membrane]
(R-HSA-9673596)
PDGFRA N659K [plasma membrane]
(R-HSA-9671535)
PDGFRA T674I [plasma membrane]
(R-HSA-9673603)
PDGFRA S601P [plasma membrane]
(R-HSA-9673600)
PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9671971)
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673609)
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9672027)
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673634)
PDGFRA D842_M844del [plasma membrane]
(R-HSA-9671526)
PDGFRA D842Y [plasma membrane]
(R-HSA-9671956)
PDGFRA D842V [plasma membrane]
(R-HSA-9671549)
PDGFRA I843_D846del [plasma membrane]
(R-HSA-9671537)
PDGFRA D842_H845del [plasma membrane]
(R-HSA-9671545)
PDGFRA D842del [plasma membrane]
(R-HSA-9671538)
PDGFRA D842_I843delinsV [plasma membrane]
(R-HSA-9671563)
PDGFRA D846Y [plasma membrane]
(R-HSA-9671958)
PDGFRA D843_845del [plasma membrane]
(R-HSA-9671552)
PDGFRA D842_D846del [plasma membrane]
(R-HSA-9671547)
PDGFRA N848K [plasma membrane]
(R-HSA-9671961)
PDGFRA Y849C [plasma membrane]
(R-HSA-9671974)
0.569
3
UniProt:Q70EK8 UBP53
0.556
5
UniProt:A2A3K4 PTPC1
0.556
3
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.556
3
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.556
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.556
5
UniProt:Q63HR2 TENS2
0.553
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.547
2
UniProt:Q8TB24 RIN3
1
RIN3 [cytosol]
(R-HSA-8875292)
0.547
2
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.547
2
IntAct:EBI-15753371 YRCPEPTIDE
0.544
3
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.536
2
UniProt:Q9H792 PEAK1
1
PEAK1 [cytosol]
(R-HSA-9715162)
0.527
2
UniProt:Q6P2E9 EDC4
1
EDC4 [cytosol]
(R-HSA-429963)
0.527
2
UniProt:Q96F86 EDC3
1
EDC3 [cytosol]
(R-HSA-429997)
0.527
2
UniProt:Q14185 DOCK1
1
DOCK1 [cytosol]
(R-HSA-372654)
0.527
2
UniProt:Q86YV5 SGK223
1
PRAG1 [cytosol]
(R-HSA-9696532)
0.527
2
UniProt:Q9H7D0 DOCK5
1
DOCK5 [cytosol]
(R-HSA-1012991)
0.527
2
UniProt:Q13325 IFIT5
1
IFIT5 [cytosol]
(R-HSA-9684472)
0.527
2
UniProt:Q92918 M4K1
0.524
5
UniProt:Q9EQG6 Kidins220
3
ARMS/KIDINS220 protein [cytosol]
(R-RNO-182094)
phospho-Kidins220 [cytosol]
(R-RNO-169869)
Kidins220 [cytosol]
(R-RNO-169880)
0.499
2
UniProt:Q96PD2 DCBD2
0.499
3
UniProt:O15524 SOCS1
1
SOCS1 [cytosol]
(R-HSA-204910)
0.488
2
UniProt:Q9H0V1 TM168
0.488
2
UniProt:Q99704 DOK1
2
p-Y362-DOK1 [cytosol]
(R-HSA-8848784)
DOK1 [cytosol]
(R-HSA-74763)
0.488
2
UniProt:O15033 AREL1
1
AREL1 [cytosol]
(R-HSA-8851648)
0.488
2
UniProt:O60496 DOK2
1
DOK2 [cytosol]
(R-HSA-204823)
0.488
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.483
3
UniProt:P17948 FLT1
1
VEGFR1 [plasma membrane]
(R-HSA-3004464)
0.471
9
UniProt:P42229 STAT5A
4
STAT5A [nucleoplasm]
(R-HSA-9701901)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
STAT5A [cytosol]
(R-HSA-380747)
0.462
2
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