Phosphorylation of pPTK2 by SRC

Stable Identifier
R-HSA-354124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of pPTK2 by SRC
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The recruitment of FADK1 to active SRC leads to the efficient tyrosine phosphorylation of multiple additional sites on FADK1. SRC trans-phosphorylates FADK1 within the kinase doman activation loop (Y576 and Y577) and within the FADK1 C-terminal domain (Y861 and Y925).
Literature References
PubMed ID Title Journal Year
11476890 Biochemical signals and biological responses elicited by the focal adhesion kinase

Schaller, MD

Biochim Biophys Acta 2001
16919435 Integrin-regulated FAK-Src signaling in normal and cancer cells

Mitra, SK, Schlaepfer, DD

Curr Opin Cell Biol 2006
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane]

Physical Entity
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of pPTK2 by SRC (Bos taurus)
Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)
Phosphorylation of pPTK2 by SRC (Canis familiaris)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Mus musculus)
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Phosphorylation of pPTK2 by SRC (Sus scrofa)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-06-16)
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