Reactome | Cytochrome c (reduced) [mitochondrial inner membrane]

Cytochrome c (reduced) [mitochondrial inner membrane]

Stable Identifier

R-HSA-352609

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ferrous cytochrome c, Cytochrome c-Fe2+

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9FKS5 CYC1B

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External Reference Information

External Reference

UniProt:P99999 CYCS

Gene Names

CYCS, CYC

Chain

initiator methionine:, chain:2-105

Reference Genes

BioGPS Gene:54205 CYCS

COSMIC (genes):CYCS CYCS

CTD Gene:54205 CYCS

dbSNP Gene:54205 CYCS

ENSEMBL:ENSG00000172115 CYCS

ENSEMBL_homo_sapiens_GENE:ENSG00000172115.9 CYCS

HGNC:19986 CYCS

KEGG Gene (Homo sapiens):54205 CYCS

Monarch:54205 CYCS

NCBI Gene:54205 CYCS

OMIM:123970 CYCS

UCSC:P99999 CYCS

Reference Transcript

RefSeq:NM_018947.5 CYCS

Other Identifiers

11722003_at

11722004_s_at

11753803_x_at

17055970

17124130

208905_PM_at

208905_at

229415_PM_at

229415_at

244546_PM_at

244546_at

2904075

3042002

3042003

3042004

3042005

3042006

3042007

3042008

3042009

3042010

3042011

3130960

3130961

3130962

35818_at

54205

70396_at

8138640

83749_at

A_24_P29665

A_24_P573978

A_32_P174083

GE61580

GO:0003824

GO:0005515

GO:0005634

GO:0005739

GO:0005743

GO:0005758

GO:0005829

GO:0006091

GO:0006122

GO:0006123

GO:0006915

GO:0008635

GO:0009055

GO:0012501

GO:0016491

GO:0020037

GO:0022900

GO:0023052

GO:0043226

GO:0043293

GO:0045333

GO:0046872

GO:0070469

GO:0097193

HMNXSV003054060

Hs.157301.0.A1_3p_at

Hs.205711.0.A1_3p_at

ILMN_1730416

M22877_at

PH_hs_0025571

TC07001207.hg

g13529022_3p_at

Participates

as an output of

as an input of

Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)

Other forms of this molecule

AcK-CYCS [mitochondrial intermembrane space]

Cytochrome c (oxidised) [mitochondrial inner membrane]

CYCS [cytosol]

CYCS [mitochondrial intermembrane space]

apo-CYCS [mitochondrial inner membrane]

Inferred To

Cycsl3 [mitochondrial inner membrane] (Rattus norvegicus)

LOC100519295 [mitochondrial inner membrane] (Sus scrofa)

Cycsl2 [mitochondrial inner membrane] (Rattus norvegicus)

LOC100621347 [mitochondrial inner membrane] (Sus scrofa)

Cytochrome c (reduced) [mitochondrial inner membrane] (Bos taurus)

Cytochrome c (reduced) [mitochondrial inner membrane] (Caenorhabditis elegans)

Cytochrome c (reduced) [mitochondrial inner membrane] (Canis familiaris)

Cytochrome c (reduced) [mitochondrial inner membrane] (Danio rerio)

Cytochrome c (reduced) [mitochondrial inner membrane] (Dictyostelium discoideum)

Cytochrome c (reduced) [mitochondrial inner membrane] (Drosophila melanogaster)

Cytochrome c (reduced) [mitochondrial inner membrane] (Gallus gallus)

Cytochrome c (reduced) [mitochondrial inner membrane] (Mus musculus)

Cytochrome c (reduced) [mitochondrial inner membrane] (Plasmodium falciparum)

Cytochrome c (reduced) [mitochondrial inner membrane] (Rattus norvegicus)

Cytochrome c (reduced) [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Cytochrome c (reduced) [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Cytochrome c (reduced) [mitochondrial inner membrane] (Sus scrofa)

Cytochrome c (reduced) [mitochondrial inner membrane] (Xenopus tropicalis)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Caenorhabditis elegans)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Gallus gallus)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Plasmodium falciparum)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Rattus norvegicus)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Sus scrofa)

Homologues of Cytochrome c (reduced) [mitochondrial inner membrane] (Xenopus tropicalis)

LOC100522842 [mitochondrial inner membrane] (Sus scrofa)

Modified Residues

Name

heme-bis-L-cysteine (ferroheme c di-L-cysteine(2-) residue) at 15

Coordinate

Modification

ferroheme c di-L-cysteine(2-) residue

PsiMod Name

heme-bis-L-cysteine

PsiMod Definition

Cross-link 2.

Name

heme-bis-L-cysteine (ferroheme c di-L-cysteine(2-) residue) at 18

Coordinate

Modification

ferroheme c di-L-cysteine(2-) residue

PsiMod Name

heme-bis-L-cysteine

PsiMod Definition

Cross-link 2.

Cross References

RefSeq

NP_061820.1

OpenTargets

ENSG00000172115

HPA

ENSG00000172115-CYCS

GeneCards

P99999

Ensembl

ENSP00000386270, ENSG00000172115, ENST00000409409, ENSP00000307786, ENST00000305786, ENST00000409764, ENSP00000387279

PRO

P99999

Pharos - Targets

P99999

Orphanet

17975

HMDB Protein

HMDBP01762

PDB

6ECJ, 5EXQ, 6DUJ, 5TY3, 2N3Y, 3NWV, 5O10, 2N9J, 1J3S, 3ZOO, 3ZCF, 6XNK, 2N9I

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	6
UniProt:O14727 APAF1	4	APAF1 [secretory granule lumen] (R-HSA-6801271) APAF1 [extracellular region] (R-HSA-6806465) APAF1 [ficolin-1-rich granule lumen] (R-HSA-6801301) APAF1 [cytosol] (R-HSA-50099)	0.688	6
UniProt:P02750 LRG1	4	LRG1 [specific granule lumen] (R-HSA-6799640) LRG1 [ficolin-1-rich granule lumen] (R-HSA-6800888) LRG1 [extracellular region] (R-HSA-6799675) LRG1 [tertiary granule lumen] (R-HSA-6800891)	0.623	4
UniProt:Q9FKS5 CYC1B			0.558	2
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q8IYG6 LRC56			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:Q9BUL5 PHF23			0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:A0A0A0MR05 A0A0A0MR05			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
IntAct:EBI-25835866 CCSB			0.556	3
UniProt:Q9UKG9-2 Q9UKG92			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
UniProt:Q1L5Z9 LONF2			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
UniProt:Q96BR5 COA7			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P06429 VE7			0.553	2
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.536	2

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