Reactome | SLC7A8-mediated uptake of neutral amino acids

SLC7A8-mediated uptake of neutral amino acids

Stable Identifier

R-HSA-352191

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC7A8-mediated uptake of neutral amino acids

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SLC7A8, complexed with SLC3A2 in the plasma membrane, mediates the uptake of neutral amino acids. The process is Na+-independent and not coupled to H+ transport. As measured by Northern blotting SLC7A8 is widely expressed in the body. In situ hybridization studies indicate that the gene product is abundant in kidney proximal tubules (Pineda et al. 1999; Park et al. 2005)

Literature References

PubMed ID	Title	Journal	Year
10391915	Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids Palacin, M, Torrents, D, Zorzano, A, Lloberas, J, López, C, Fernández, E, Pineda, M, Camps, M, Estévez, R	J Biol Chem	1999
15918515	Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule Park, KJ, Chairoungdua, A, Endou, H, Kim, JK, Kim, DK, Kim, IJ, Lee, S, Park, SY, Kanai, Y, Jung, KY, Choi, BK	Arch Pharm Res	2005