Reactome | SLC6A15-mediated amino acid uptake

SLC6A15-mediated amino acid uptake

Stable Identifier

R-HSA-352059

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
      - SLC6A15-mediated amino acid uptake (Homo sapiens)
  - Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
    - Amino acid transport across the plasma membrane (Homo sapiens)
      - SLC6A15-mediated amino acid uptake (Homo sapiens)

General

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SLC6A15, associated with the plasma membrane, mediates the uptake of a broad range of amino acids plus a sodium ion, transporting branched-chain amiono acids and methionine most efficiently. The human protein is expressed in the brain (Takanaga et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16226721	Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain Mackenzie, B, Takanaga, H, Peng, JB, Hediger, MA	Biochem Biophys Res Commun	2005