SLC6A18 transports Gly from extracellular region to cytosol

Stable Identifier
R-HSA-351963
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The protein SLC6A18 was first identified as an amino acid transporter based on sequence similarity to other members of the SLC6 protein family (Hoglund et al. 2005). It is annotated here as mediating glycine uptake based on the phenotype of mice homozygous for a null mutation in the homologous gene (Quan et al. 2004).

Literature References
PubMed ID Title Journal Year
15121838 Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2

Quan, H, Athirakul, K, Wetsel, WC, Torres, GE, Stevens, R, Coffman, TM, Caron, MG

Mol Cell Biol 2004
16125675 The repertoire of solute carriers of family 6: identification of new human and rodent genes

Höglund, PJ, Adzic, D, Scicluna, SJ, Lindblom, J, Fredriksson, R

Biochem Biophys Res Commun 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
amino acid transmembrane transporter activity of SLC6A18 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created