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Mitochondrial recruitment of Drp1
Stable Identifier
R-HSA-351948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Mitochondrial recruitment of Drp1 (Homo sapiens)
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Adenoviral expression of the BAP31 cleavage product, p20 causes early release of Ca2+ from the ER, concomitant uptake of Ca2+ into mitochondria, and recruitment of Drp1 to the mitochondria (Breckenridge et al., 2003). Drp1 mediates scission of the outer mitochondrial membrane, resulting in dramatic fragmentation and fission of the mitochondrial network.
Literature References
PubMed ID
Title
Journal
Year
12668660
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
Stojanovic, M
,
Marcellus, RC
,
Shore, GC
,
Breckenridge, DG
J Cell Biol
2003
Participants
Input
DNM1L [cytosol]
(Homo sapiens)
Output
DNM1L [mitochondrial outer membrane]
(Homo sapiens)
Participates
as an event of
Apoptotic execution phase (Homo sapiens)
This event is regulated
Positively by
Regulator
BCAP31(2-164) [endoplasmic reticulum membrane]
(Homo sapiens)
Orthologous Events
Mitochondrial recruitment of Drp1 (Bos taurus)
Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)
Mitochondrial recruitment of Drp1 (Canis familiaris)
Mitochondrial recruitment of Drp1 (Danio rerio)
Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)
Mitochondrial recruitment of Drp1 (Drosophila melanogaster)
Mitochondrial recruitment of Drp1 (Gallus gallus)
Mitochondrial recruitment of Drp1 (Mus musculus)
Mitochondrial recruitment of Drp1 (Plasmodium falciparum)
Mitochondrial recruitment of Drp1 (Rattus norvegicus)
Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)
Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)
Mitochondrial recruitment of Drp1 (Sus scrofa)
Authored
Schulze-Osthoff, K (2008-05-18)
Reviewed
Ranganathan, S (2008-06-11)
Created
Matthews, L (2008-05-29)
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