Mitochondrial recruitment of Drp1

Stable Identifier
R-HSA-351948
Type
Reaction [transition]
Species
Homo sapiens
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Adenoviral expression of the BAP31 cleavage product, p20 causes early release of Ca2+ from the ER, concomitant uptake of Ca2+ into mitochondria, and recruitment of Drp1 to the mitochondria (Breckenridge et al., 2003). Drp1 mediates scission of the outer mitochondrial membrane, resulting in dramatic fragmentation and fission of the mitochondrial network.

Literature References
PubMed ID Title Journal Year
12668660 Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

Breckenridge, DG, Stojanovic, M, Marcellus, RC, Shore, GC

J Cell Biol 2003
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