Reactome | Mitochondrial recruitment of Drp1

Mitochondrial recruitment of Drp1

Stable Identifier

R-HSA-351948

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

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Adenoviral expression of the BAP31 cleavage product, p20 causes early release of Ca2+ from the ER, concomitant uptake of Ca2+ into mitochondria, and recruitment of Drp1 to the mitochondria (Breckenridge et al., 2003). Drp1 mediates scission of the outer mitochondrial membrane, resulting in dramatic fragmentation and fission of the mitochondrial network.

Literature References

PubMed ID	Title	Journal	Year
12668660	Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol Breckenridge, DG, Stojanovic, M, Marcellus, RC, Shore, GC	J Cell Biol	2003