Caspase-mediated cleavage of Etk

Stable Identifier
R-HSA-351849
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Caspase-mediated cleavage of Etk
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Cleavage of Etk by caspase-3 stimulates its kinase activity. Overexpression of the fragment induces apoptosis (Wu et al.,2001).
Literature References
PubMed ID Title Journal Year
11278797 Proteolytic activation of ETK/Bmx tyrosine kinase by caspases

Wu, YM, Huang, CL, Huang, CY, Kung, HJ

J Biol Chem 2001
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Output
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Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of Etk (Bos taurus)
Caspase-mediated cleavage of Etk (Canis familiaris)
Caspase-mediated cleavage of Etk (Drosophila melanogaster)
Caspase-mediated cleavage of Etk (Gallus gallus)
Caspase-mediated cleavage of Etk (Mus musculus)
Caspase-mediated cleavage of Etk (Rattus norvegicus)
Caspase-mediated cleavage of Etk (Sus scrofa)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-29)
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