Reactome | Spermine => N-acetylated spermine

Spermine => N-acetylated spermine

Stable Identifier

R-HSA-351207

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Literature References

PubMed ID	Title	Journal	Year
15784477	Polyamines: metabolism and implications in human diseases Moinard, C, Cynober, L, de Bandt, JP	Clin Nutr	2005
1985966	Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase Casero RA, Jr, Celano, P, Ervin, SJ, Applegren, NB, Wiest, L, Pegg, AE	J Biol Chem	1991