Spermine => N-acetylated spermine

Stable Identifier
R-HSA-351207
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).
Literature References
PubMed ID Title Journal Year
1985966 Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero RA, Jr, Applegren, NB, Pegg, AE, Ervin, SJ, Wiest, L, Celano, P

J Biol Chem 1991
15784477 Polyamines: metabolism and implications in human diseases

de Bandt, JP, Cynober, L, Moinard, C

Clin Nutr 2005
Participants
Participates
Catalyst Activity

diamine N-acetyltransferase activity of SAT1 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Cite Us!