Reactome | Spermine => N-acetylated spermine

Spermine => N-acetylated spermine

Stable Identifier

R-HSA-351207

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Literature References

PubMed ID	Title	Journal	Year
1985966	Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase Casero RA, Jr, Applegren, NB, Pegg, AE, Ervin, SJ, Wiest, L, Celano, P	J Biol Chem	1991
15784477	Polyamines: metabolism and implications in human diseases de Bandt, JP, Cynober, L, Moinard, C	Clin Nutr	2005