Spermine => N-acetylated spermine

Stable Identifier
R-HSA-351207
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Spermine => N-acetylated spermine
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Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Literature References
PubMed ID Title Journal Year
1985966 Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero RA, Jr, Applegren, NB, Pegg, AE, Ervin, SJ, Wiest, L, Celano, P

J Biol Chem 1991
15784477 Polyamines: metabolism and implications in human diseases

de Bandt, JP, Cynober, L, Moinard, C

Clin Nutr 2005
Participants
Input
Output
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as an event of
Catalyst Activity

diamine N-acetyltransferase activity of SAT1 [cytosol]

Physical Entity
SAT1 [cytosol] (Homo sapiens)
Activity
diamine N-acetyltransferase activity (GO:0004145)
Orthologous Events
Spermine => N-acetylated spermine (Bos taurus)
Spermine => N-acetylated spermine (Caenorhabditis elegans)
Spermine => N-acetylated spermine (Danio rerio)
Spermine => N-acetylated spermine (Dictyostelium discoideum)
Spermine => N-acetylated spermine (Drosophila melanogaster)
Spermine => N-acetylated spermine (Mus musculus)
Spermine => N-acetylated spermine (Rattus norvegicus)
Spermine => N-acetylated spermine (Saccharomyces cerevisiae)
Spermine => N-acetylated spermine (Schizosaccharomyces pombe)
Spermine => N-acetylated spermine (Sus scrofa)
Spermine => N-acetylated spermine (Xenopus tropicalis)
Cross References
Rhea
Authored
Gopinathrao, G  (2008-05-21)
Reviewed
D'Eustachio, P  (2008-06-12)
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