Spermine => N-acetylated spermine

Stable Identifier
R-HSA-351207
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Spermine => N-acetylated spermine
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Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Literature References
PubMed ID Title Journal Year
15784477 Polyamines: metabolism and implications in human diseases

Moinard, C, Cynober, L, de Bandt, JP

Clin Nutr 2005
1985966 Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero RA, Jr, Celano, P, Ervin, SJ, Applegren, NB, Wiest, L, Pegg, AE

J Biol Chem 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
diamine N-acetyltransferase activity of SAT1 [cytosol]
Physical Entity
SAT1 [cytosol]
Activity
diamine N-acetyltransferase activity (0004145)
Orthologous Events
Spermine => N-acetylated spermine (Bos taurus)
Spermine => N-acetylated spermine (Caenorhabditis elegans)
Spermine => N-acetylated spermine (Canis familiaris)
Spermine => N-acetylated spermine (Danio rerio)
Spermine => N-acetylated spermine (Dictyostelium discoideum)
Spermine => N-acetylated spermine (Drosophila melanogaster)
Spermine => N-acetylated spermine (Mus musculus)
Spermine => N-acetylated spermine (Rattus norvegicus)
Spermine => N-acetylated spermine (Saccharomyces cerevisiae)
Spermine => N-acetylated spermine (Schizosaccharomyces pombe)
Spermine => N-acetylated spermine (Sus scrofa)
Spermine => N-acetylated spermine (Xenopus tropicalis)
Cross References
Rhea
Authored
Gopinathrao, G  (2008-05-21)
Reviewed
D'Eustachio, P  (2008-06-12)