Spermine => N-acetylated spermine

Stable Identifier
R-HSA-351207
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Literature References
PubMed ID Title Journal Year
15784477 Polyamines: metabolism and implications in human diseases

Moinard, C, Cynober, L, de Bandt, JP

Clin Nutr 2005
1985966 Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero RA, Jr, Celano, P, Ervin, SJ, Applegren, NB, Wiest, L, Pegg, AE

J Biol Chem 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
diamine N-acetyltransferase activity of SAT1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed