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N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal)
Stable Identifier
R-HSA-351201
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of polyamines (Homo sapiens)
Interconversion of polyamines (Homo sapiens)
N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) is a crucial step in the regulation of the cellular polyamine levels in eukaryotic cells. The kinetics of this enzyme has been already elucidated (Hedge et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17516632
Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase
Vetting, MW
,
Yu, M
,
Hegde, SS
,
Chandler, J
,
Blanchard, JS
Biochemistry
2007
Participants
Input
NASPM [cytosol]
Output
NASPM [peroxisomal matrix]
Participates
as an event of
Interconversion of polyamines (Homo sapiens)
Event Information
Go Biological Process
peroxisomal transport (0043574)
Authored
Gopinathrao, G (2008-05-21)
Reviewed
D'Eustachio, P (2008-06-12)
Created
Gopinathrao, G (2008-05-22)
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