Reactome | Agmatine biosynthesis

Agmatine biosynthesis

Stable Identifier

R-HSA-351143

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Agmatine is an amine formed by decarboxylation of L-arginine and hydrolyzed to putrescine. Agmatine binds to several target receptors in the brain and has been proposed to be a neuromodulator. Agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation (Moinard et al. 2005; Morris 2003; Reghunathan 2006; Satriano, 2003).

Literature References

PubMed ID	Title	Journal	Year
15028567	Vertebrate agmatinases: what role do they play in agmatine catabolism? Morris SM, Jr	Ann N Y Acad Sci	2003
15028568	Agmatine: at the crossroads of the arginine pathways Satriano, J	Ann N Y Acad Sci	2003
17025265	Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence Regunathan, S	AAPS J	2006
15784477	Polyamines: metabolism and implications in human diseases Moinard, C, Cynober, L, de Bandt, JP	Clin Nutr	2005