Thyroxine is deiodinated to reverse triiodothyronine (RT3)

Stable Identifier
R-HSA-350869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Type III iodothyronine deiodinase (DIO3) is an integral membrane protein (Baqui M et al, 2003) and catalyzes the conversion of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). Both RT3 and T2 are inactive metabolites. It is thought DIO3 plays an essential role for regulation of thyroid hormone inactivation during embryological development.

Literature References
PubMed ID Title Journal Year
7593630 Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme

Salvatore, D, Low, SC, Berry, M, Maia, AL, Harney, JW, Croteau, W, St Germain, DL, Larsen, PR

J Clin Invest 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thyroxine 5'-deiodinase activity of DIO3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created