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apoTF [extracellular region]
Stable Identifier
R-HSA-350754
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Serotransferrin
Locations in the PathwayBrowser for interactor UniProt:Q3KNW5%20SLC10A6
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
apo-Transferrin dissociates from the receptor complex (Homo sapiens)
apoTF [extracellular region] (Homo sapiens)
apoTF binds 2Fe3+ to form holoTF (Homo sapiens)
apoTF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02787 TF
Gene Names
TF, PRO1400
Chain
signal peptide:1-19, chain:20-698
Reference Genes
BioGPS Gene:7018 TF
COSMIC (genes):TF TF
CTD Gene:7018 TF
dbSNP Gene:7018 TF
ENSEMBL:ENSG00000091513 TF
ENSEMBL_homo_sapiens_GENE:ENSG00000091513.16 TF
HGNC:11740 TF
KEGG Gene (Homo sapiens):7018 TF
Monarch:7018 TF
NCBI Gene:7018 TF
OMIM:190000 TF
UCSC:P02787 TF
Reference Transcript
RefSeq:NM_001063.3 TF
Other Identifiers
11719658_a_at
11751529_a_at
11756783_a_at
16945870
16945907
203400_PM_s_at
203400_s_at
214063_PM_s_at
214063_s_at
2555254
2643236
2643237
2643240
2643241
2643243
2643244
2643248
2643249
2643251
2643252
2643254
2643257
2643264
2643265
2643267
2643268
2643271
2643273
2643274
2643275
2643277
2643279
2643280
2643281
2643282
2643283
2643284
2643285
2643286
2643287
2643288
2643289
2643290
2643291
2643292
2643293
2643294
2643321
2643323
2643325
2643326
2643327
2643328
2643329
2643330
2643331
2643332
32538_at
7018
8082797
8082816
A_14_P129777
A_23_P212500
A_23_P212508
GE58831
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005788
GO:0005886
GO:0005905
GO:0006351
GO:0006355
GO:0006811
GO:0006826
GO:0006879
GO:0007010
GO:0007015
GO:0008198
GO:0008199
GO:0009617
GO:0009925
GO:0009986
GO:0010008
GO:0016020
GO:0016192
GO:0016324
GO:0019731
GO:0023052
GO:0030139
GO:0030154
GO:0030316
GO:0030669
GO:0031410
GO:0031647
GO:0031982
GO:0034756
GO:0034774
GO:0034986
GO:0042327
GO:0043226
GO:0045178
GO:0045780
GO:0045893
GO:0046872
GO:0048260
GO:0048471
GO:0048856
GO:0048870
GO:0055037
GO:0055065
GO:0060395
GO:0070062
GO:0070371
GO:0071281
GO:0072562
GO:0098542
GO:0140104
GO:1990459
GO:1990712
GO:2000147
HMNXSV003052276
ILMN_1768425
PH_hs_0025298
S95936_at
g4557870_3p_s_at
Participates
as a member of
Platelet releasate secretory granule proteins [extracellular region] (Homo sapiens)
as an input of
apoTF binds 2Fe3+ to form holoTF (Homo sapiens)
as an output of
apo-Transferrin dissociates from the receptor complex (Homo sapiens)
as a component of
apoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Other forms of this molecule
apoTF [clathrin-coated endocytic vesicle membrane]
TF [secretory granule lumen]
p-TF [endoplasmic reticulum lumen]
TF [endoplasmic reticulum lumen]
apoTF [endosome membrane]
Inferred To
apoTF [extracellular region]
(Drosophila melanogaster)
apoTF [extracellular region]
(Gallus gallus)
apoTF [extracellular region]
(Mus musculus)
apoTF [extracellular region]
(Rattus norvegicus)
apoTF [extracellular region]
(Xenopus tropicalis)
TF [extracellular region]
(Bos taurus)
TF [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001054.1
OpenTargets
ENSG00000091513
GeneCards
P02787
HPA
ENSG00000091513-TF
Ensembl
ENSG00000091513
,
ENST00000402696
,
ENSP00000385834
ZINC target
P02787
PRO
P02787
Pharos - Targets
P02787
Orphanet
15600
HMDB Protein
HMDBP02076
PDB
4X1D
,
3V83
,
1A8E
,
5H52
,
4X1B
,
3V8X
,
3S9M
,
1BTJ
,
2O84
,
6CTC
,
1JQF
,
3QYT
,
6SOY
,
3SKP
,
1D3K
,
5WTD
,
6SOZ
,
1RYO
,
7FFU
,
7Q1L
,
1SUV
,
5Y6K
,
5DYH
,
6D04
,
2HAV
,
6JAS
,
1FQE
,
3S9N
,
3S9L
,
2O7U
,
1OQG
,
1BP5
,
1DTG
,
1FQF
,
1OQH
,
6UJ6
,
1N7X
,
3V89
,
5X5P
,
1D4N
,
8BRC
,
1A8F
,
1N7W
,
7FFM
,
2HAU
,
6D05
,
1N84
,
3FGS
,
4H0W
,
6D03
,
1B3E
,
3VE1
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02786 TFRC
5
TFRC(1-760) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869124)
TFRC(1-760) [Golgi membrane]
(R-HSA-434330)
TFRC(1-760) [cytoplasmic vesicle membrane]
(R-HSA-434196)
TFRC(1-760) [endosome membrane]
(R-HSA-8961829)
TFRC(1-760) [plasma membrane]
(R-HSA-917983)
0.852
7
UniProt:A5K736 A5K736
0.733
9
UniProt:Q9K0U9 TBPA
0.632
4
UniProt:Q09057 TBPB1
0.618
3
UniProt:P01350 GAST
1
GAST(76-92) [extracellular region]
(R-HSA-870266)
0.618
5
UniProt:Q9K0V0 TBPB
0.558
2
UniProt:Q9BXS9-3 SLC26A6
0.556
3
UniProt:Q96KR6 F210B
0.556
3
UniProt:O15173 PGRMC2
4
PGRMC2 [nuclear envelope]
(R-HSA-9707674)
PGRMC2 [nucleoplasm]
(R-HSA-9707859)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
PGRMC2 [endosome membrane]
(R-HSA-9715090)
0.556
3
UniProt:O43315 AQP9
1
AQP9 [plasma membrane]
(R-HSA-431761)
0.556
3
UniProt:A8MZ59 LEUTX
1
LEUTX [nucleoplasm]
(R-HSA-9817277)
0.556
3
UniProt:O15529 GPR42
0.556
3
UniProt:Q8NBJ4 GOLM1
2
p-GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956938)
GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956710)
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q99523 SORT1
2
SORT1 [cytoplasmic vesicle membrane]
(R-HSA-434221)
SORT1 [Golgi membrane]
(R-HSA-434332)
0.556
3
UniProt:Q4KMG9 TM52B
0.556
3
UniProt:O00501 CLDN5
2
CLDN5 [cell junction]
(R-HSA-421264)
CLDN5 [plasma membrane]
(R-HSA-419991)
0.556
3
UniProt:Q96TC7 RMD3
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q8N9I0 SYT2
3
SYT2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869116)
SYT2 [plasma membrane]
(R-HSA-168795)
SYT2 [synaptic vesicle membrane]
(R-HSA-194786)
0.556
3
UniProt:O43278-2 SPINT1
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:P08034 GJB1
2
GJB1 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190636)
GJB1 [endoplasmic reticulum membrane]
(R-HSA-190656)
0.556
3
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.527
6
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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