Caspase-mediated cleavage of MASK

Stable Identifier
R-HSA-350651
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Caspase-mediated cleavage of MASK
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MASK is cleaved in vitro by caspase 3 . C-terminally truncated forms of MASK can both induce apoptosis upon overexpression in mammalian cells (Dan et al., 2002).

Literature References
PubMed ID Title Journal Year
11741893 Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties

Dan, I, Ong, SE, Watanabe, NM, Blagoev, B, Nielsen, MM, Kajikawa, E, Kristiansen, TZ, Mann, M, Pandey, A

J Biol Chem 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase-mediated cleavage of MASK (Canis familiaris)
Caspase-mediated cleavage of MASK (Danio rerio)
Caspase-mediated cleavage of MASK (Drosophila melanogaster)
Caspase-mediated cleavage of MASK (Gallus gallus)
Caspase-mediated cleavage of MASK (Mus musculus)
Caspase-mediated cleavage of MASK (Rattus norvegicus)
Caspase-mediated cleavage of MASK (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-20)