Caspase-mediated cleavage of MASK

Stable Identifier
R-HSA-350651
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of MASK
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MASK is cleaved in vitro by caspase 3 . C-terminally truncated forms of MASK can both induce apoptosis upon overexpression in mammalian cells (Dan et al., 2002).
Literature References
PubMed ID Title Journal Year
11741893 Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties

Dan, I, Ong, SE, Watanabe, NM, Blagoev, B, Nielsen, MM, Kajikawa, E, Kristiansen, TZ, Mann, M, Pandey, A

J Biol Chem 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of MASK (Bos taurus)
Caspase-mediated cleavage of MASK (Canis familiaris)
Caspase-mediated cleavage of MASK (Danio rerio)
Caspase-mediated cleavage of MASK (Drosophila melanogaster)
Caspase-mediated cleavage of MASK (Gallus gallus)
Caspase-mediated cleavage of MASK (Mus musculus)
Caspase-mediated cleavage of MASK (Rattus norvegicus)
Caspase-mediated cleavage of MASK (Sus scrofa)
Caspase-mediated cleavage of MASK (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-20)
Cite Us!