Agmatine + H2O <=> putrescine + urea

Stable Identifier
R-HSA-350604
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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As it hydrolyzes a guanidino group within agmatine and also contains signature amino acid residues that act as ligand binding sites for the potential Mn(++) cofactor, agmatinase is classified as a member of the arginase superfamily (Morris, 2003).

Literature References
PubMed ID Title Journal Year
11804860 Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus

Mistry, SK, Burwell, TJ, Chambers, RM, Rudolph-Owen, L, Spaltmann, F, Cook, WJ, Morris SM, Jr

Am J Physiol Gastrointest Liver Physiol 2002
11914032 Cloning and characterization of human agmatinase

Iyer, RK, Kim, HK, Tsoa, RW, Grody, WW, Cederbaum, SD

Mol Genet Metab 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
agmatinase activity of AGMAT(1-?) [mitochondrion]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed