Reactome | Antizyme inhibitor binds to OAZ and stablizes ODC complex

Antizyme inhibitor binds to OAZ and stablizes ODC complex

Stable Identifier

R-HSA-350600

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Antizyme inhibitor binds to OAZ and stablizes ODC complex

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Antizyme inhibitor blocks the effects of antizyme on ODC. It has substantial similarity to ODC itself but has no ODC activity. It binds to antizyme more tightly than ODC displacing ODC from the antizyme-ODC complex. Recent studies have shown that antizyme inhibitor is able to disrupt the interaction between all forms of mammalian antizyme and ODC (Murakami et al., 1996, Nilsson et al., 2000, Mangold and Leberer, 2005).

Literature References

PubMed ID	Title	Journal	Year
17900240	Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Heiskala, M, Mäkitie, LT, Pelander, A, Kanerva, K, Andersson, LC	Biochem J	2008
9349715	Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor Murakami, Y, Koguchi, K, Hayashi, T, Hayashi, S, Matsufuji, S, Kobayashi, S	Biochim Biophys Acta	1997
15491992	Degradation of antizyme inhibitor, an ornithine decarboxylase homologous protein, is ubiquitin-dependent and is inhibited by antizyme Kahana, C, Bercovich, Z	J Biol Chem	2004