LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

Stable Identifier
Reaction [omitted]
Homo sapiens
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Megalin (LRP2, glycoprotein 330) is a member of the low density lipoprotein receptor family and is abundant in kidney proximal tubules (Kounnas et al. 1995, Hjalm et al. 1996). LRP2 mediates the endocytic uptake of GC:25(OH)D complexes, thereby preventing the loss of 25-hydroxyvitamin D (calcidiol, 25(OH)D) in urine (Nykjaer et al. 1999, Kaseda et al. 2011).

Literature References
PubMed ID Title Journal Year
10052453 An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Nykjaer, A, Dragun, D, Walther, D, Vorum, H, Jacobsen, C, Herz, J, Melsen, F, Christensen, EI, Willnow, TE

Cell 1999
21595846 Role of megalin and cubilin in the metabolism of vitamin D(3)

Kaseda, R, Hosojima, M, Sato, H, Saito, A

Ther Apher Dial 2011
7768901 Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

Kounnas, MZ, Loukinova, EB, Stefansson, S, Harmony, JA, Brewer, BH, Strickland, DK, Argraves, WS

J Biol Chem 1995
8706697 Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

Hjalm, G, Murray, E, Crumley, G, Harazim, W, Lundgren, S, Onyango, I, Ek, B, Larsson, M, Juhlin, C, Hellman, P, Davis, H, Akerstrom, G, Rask, L, Morse, B

Eur J Biochem 1996
Catalyst Activity

cargo receptor activity of LRP2 [plasma membrane]

Orthologous Events
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