LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

Stable Identifier
R-HSA-350168
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Megalin (LRP2, glycoprotein 330) is a member of the low density lipoprotein receptor family and is abundant in kidney proximal tubules (Kounnas et al. 1995, Hjalm et al. 1996). LRP2 mediates the endocytic uptake of GC:25(OH)D complexes, thereby preventing the loss of 25-hydroxyvitamin D (calcidiol, 25(OH)D) in urine (Nykjaer et al. 1999, Kaseda et al. 2011).

Literature References
PubMed ID Title Journal Year
10052453 An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Nykjaer, A, Dragun, D, Walther, D, Vorum, H, Jacobsen, C, Herz, J, Melsen, F, Christensen, EI, Willnow, TE

Cell 1999
21595846 Role of megalin and cubilin in the metabolism of vitamin D(3)

Kaseda, R, Hosojima, M, Sato, H, Saito, A

Ther Apher Dial 2011
7768901 Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

Kounnas, MZ, Loukinova, EB, Stefansson, S, Harmony, JA, Brewer, BH, Strickland, DK, Argraves, WS

J Biol Chem 1995
8706697 Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

Hjalm, G, Murray, E, Crumley, G, Harazim, W, Lundgren, S, Onyango, I, Ek, B, Larsson, M, Juhlin, C, Hellman, P, Davis, H, Akerstrom, G, Rask, L, Morse, B

Eur J Biochem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cargo receptor activity of LRP2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!