LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

Stable Identifier
Reaction [omitted]
Homo sapiens
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Megalin (LRP2, glycoprotein 330) is a member of the low density lipoprotein receptor family and is abundant in kidney proximal tubules (Kounnas et al. 1995, Hjalm et al. 1996). LRP2 complexed with LDLRAP1 (low density lipoprotein receptor adapter protein 1, aka ARH) mediates the endocytic uptake of GC:25(OH)D complexes, thereby preventing the loss of 25-hydroxyvitamin D (calcidiol, 25(OH)D) in urine (Nykjaer et al. 1999, Kaseda et al. 2011).
Literature References
PubMed ID Title Journal Year
21595846 Role of megalin and cubilin in the metabolism of vitamin D(3)

Hosojima, M, Sato, H, Kaseda, R, Saito, A

Ther Apher Dial 2011
10052453 An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Melsen, F, Christensen, EI, Jacobsen, C, Vorum, H, Nykjaer, A, Willnow, TE, Herz, J, Walther, D, Dragun, D

Cell 1999
7768901 Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

Brewer, BH, Stefansson, S, Harmony, JA, Loukinova, EB, Kounnas, MZ, Strickland, DK, Argraves, WS

J Biol Chem 1995
8706697 Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

Lundgren, S, Murray, E, Larsson, M, Crumley, G, Hellman, P, Akerstrom, G, Juhlin, C, Ek, B, Morse, B, Davis, H, Rask, L, Onyango, I, Harazim, W, Hjalm, G

Eur J Biochem 1996
Catalyst Activity

cargo receptor activity of LRP2:LDLRAP1 [plasma membrane]

Orthologous Events
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