LGMN degrades GC

Stable Identifier
R-HSA-350158
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Mammalian legumain (LGMN, asparagine-specific endoprotease) is a subfamily of cysteine proteases with no homology to other known proteases and is found in a wide range of organisms from parasites to plants and animals. LGMN requires acidic conditions for its degradative activity. Cubilin (CUBN), once released from the complex, cycles back to the cell surface. Free 25-hydroxyvitamin D (calcidiol, 25(OH)D) becomes available for further processing (Nykjaer et al. 1999).

Literature References
PubMed ID Title Journal Year
10052453 An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Nykjaer, A, Dragun, D, Walther, D, Vorum, H, Jacobsen, C, Herz, J, Melsen, F, Christensen, EI, Willnow, TE

Cell 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of LGMN [lysosomal lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed