VD3 translocates from extracellular region to ER membrane

Stable Identifier
R-HSA-350147
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, extracellular region
ReviewStatus
5/5
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VD3 translocates from extracellular region to ER membrane
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Once vitamin D3 (VD3) is released from vitamin D binding protein (GC, DBP), it translocates from the extracellular region to the ER membrane, becoming available for hydroxylation by the microsomal enzyme CYP2R1 (Shinkyo et al. 2004).
Literature References
PubMed ID Title Journal Year
15465040 Metabolism of vitamin D by human microsomal CYP2R1

Shinkyo, R, Ohta, M, Sakaki, T, Kamakura, M, Inouye, K

Biochem Biophys Res Commun 2004
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Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-05-14)
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