pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

Stable Identifier
R-HSA-349657
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
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Pre-beta HDL (lipid-poor apoA-I) interacts with phospholipid- and cholesterol-rich membrane patches formed through the action of ABCA1, binding these two lipids to form a discoidal (small nascent) HDL particle (HDL 3c - Kontush and Chapman 2006).

Literature References
PubMed ID Title Journal Year
17478755 ABCA1-induced cell surface binding sites for ApoA-I

Phillips, MC, Rothblat, GH, Ghering, AB, Davidson, WS, Lund-Katz, S, Vedhachalam, C

Arterioscler Thromb Vasc Biol 2007
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Orthologous Events
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Xenopus tropicalis)
Authored
D'Eustachio, P  (2008-05-12)
Reviewed
Jassal, B  (2008-06-13)
Created
D'Eustachio, P  (2008-05-12)
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